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膳食多酚对高脂饮食诱导脂代谢紊乱及相关疾病作用研究进展

  • 赵钜阳 ,
  • 李玉奇 ,
  • 徐朔 ,
  • 陈逸玉 ,
  • 苏灿 ,
  • 李文兰 ,
  • 高世勇
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  • 1(哈尔滨商业大学,药物研究所博士后科研工作站,黑龙江 哈尔滨,150076)
    2(哈尔滨商业大学 旅游烹饪学院,黑龙江 哈尔滨,150028)
第一作者:博士,副教授(李文兰教授和高世勇教授为共同通信作者,E-mail:lwldzd@163.com;sygao2002@163.com)

收稿日期: 2024-04-09

  修回日期: 2024-07-17

  网络出版日期: 2025-04-29

基金资助

黑龙江省自然科学博士后基金面上项目(LBH-Z22204);黑龙江省哲学社科专项项目(23JYA044);2023年度哈尔滨商业大学“青年科研创新人才”培育计划项目(2023-KYYWF-0992)

Research progress on the effects of dietary polyphenols on high-fat diet induced lipid metabolism disorders and related diseases

  • ZHAO Juyang ,
  • LI Yuqi ,
  • XU Shuo ,
  • CHEN Yiyu ,
  • SU Can ,
  • LI Wenlan ,
  • GAO Shiyong
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  • 1(Postdoctoral Programme of Meteria Medical Institute, Harbin University of Commerce, Harbin 150076, China)
    2(College of Tourism and Cuisine, Harbin University of Commerce, Harbin 150028, China)

Received date: 2024-04-09

  Revised date: 2024-07-17

  Online published: 2025-04-29

摘要

长期的高脂饮食(high fat diet, HFD)会严重影响到人体的脂质代谢并易导致肥胖、非酒精性脂肪肝、二型糖尿病等疾病的发生。多酚具有抗氧化、抗炎、降血脂、增强免疫等多种生理调节功能,近年来研究发现多酚还可以调节由HFD导致的脂质代谢紊乱,并改善相关疾病问题。这主要是通过调节甘油与脂肪酸代谢、上调与胰岛素信号通路相关蛋白的表达胰岛素抵抗、调节肠道微生物菌群分布与相对丰度、调节炎症应激反应等途径实现的。从肝脏、血液、胰岛、肠道等多个方面改善脂质代谢通路,对HFD导致脂质代谢异常及相关疾病具有积极的调节作用。该文对多酚干预高脂饮食诱导脂代谢紊乱的调节机理及对相关疾病的影响作简要论述,有望为多酚调节脂代谢紊乱机制的深入研究提供思路,为开发膳食多酚功能性产品提供理论依据。

本文引用格式

赵钜阳 , 李玉奇 , 徐朔 , 陈逸玉 , 苏灿 , 李文兰 , 高世勇 . 膳食多酚对高脂饮食诱导脂代谢紊乱及相关疾病作用研究进展[J]. 食品与发酵工业, 2025 , 51(7) : 360 -370 . DOI: 10.13995/j.cnki.11-1802/ts.039497

Abstract

A long-term high-fat diet (HFD) exerts profound effects on lipid metabolism in the human body, leading to obesity, nonalcoholic fatty liver disease, diabetes mellitus type 2, and other related disorders.Recent research has shed light on the diverse physiological regulatory functions of polyphenols, encompassing antioxidation, anti-inflammation, blood lipid reduction, and immune enhancement.This paper provides a concise discussion on the underlying mechanisms through which polyphenols ameliorate HFD-induced lipid metabolism disorders while also exploring their impact on associated diseases.The regulatory effect primarily involves modulation of glycerol and fatty acid metabolism, upregulation of proteins implicated in the insulin signaling pathway, regulation of intestinal microflora composition and abundance as well as modulation of inflammatory stress response.These findings are expected to offer valuable insights into comprehending the mechanism underlying polyphenol-mediated regulation of lipid metabolism disorders and provide a theoretical foundation for developing functional dietary products enriched with polyphenols.

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