研究报告

大鲵骨肽缓解小鼠高尿酸作用研究

  • 郑小莉 ,
  • 陈德经 ,
  • 苏文 ,
  • 江海 ,
  • 曾允灏 ,
  • 祁珊珊
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  • 1(陕西理工大学 生物科学与工程学院,陕西,汉中,723001)
    2(陕西理工大学 陕西省资源生物重点实验室,陕西,汉中,723001)
第一作者:硕士研究生(陈德经教授为通信作者,E-mail:cdjslg@126.com)

收稿日期: 2024-01-30

  修回日期: 2024-05-27

  网络出版日期: 2025-05-28

基金资助

陕西理工大学“市校共建”科研专项(SXZC202101)

Effect of bone peptide of giant salamander on alleviating hyperuric acid in mice

  • ZHENG Xiaoli ,
  • CHEN Dejing ,
  • SU Wen ,
  • JIANG Hai ,
  • ZENG Yunhao ,
  • QI Shanshan
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  • 1(School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723001, China)
    2(Shaanxi Provincial Key Laboratory of Resource Biology, Shaanxi University of Technology, Hanzhong 723001, China)

Received date: 2024-01-30

  Revised date: 2024-05-27

  Online published: 2025-05-28

摘要

该研究以氧嗪酸钾诱导的高尿酸血症小鼠模型为对象,来评价不同剂量大鲵骨肽(Andrias davidianus bone peptides,ADBP)[150 mg/(kg·bw)、300 mg/(kg·bw)和600 mg/(kg·bw)]降尿酸功效。结果表明,ADBP可显著降低血清中尿酸(uric acid,UA)、肌酐和尿素氮水平,有效抑制UA合成相关酶,黄嘌呤氧化酶(xanthine oxidas,XOD)和腺苷脱氨酶的活力,下调高尿酸血症小鼠肝脏中XOD的mRNA表达水平。ADBP通过调节氧化应激(总抗氧化能力、超氧化物歧化酶、谷胱甘肽过氧化物酶、丙二醛含量),抑制促炎细胞因子(CXCL1、IL-1β、IL-6、TNF-α)水平,改善了肝脏和肾脏的组织病理学损伤。研究证实ADBP对高尿酸血症小鼠有明显的降尿酸作用,对长期高尿酸引起的机体损伤有一定的修复作用,可作缓解和治疗高尿酸血症的物质。

本文引用格式

郑小莉 , 陈德经 , 苏文 , 江海 , 曾允灏 , 祁珊珊 . 大鲵骨肽缓解小鼠高尿酸作用研究[J]. 食品与发酵工业, 2025 , 51(8) : 264 -275 . DOI: 10.13995/j.cnki.11-1802/ts.038766

Abstract

In this study, the uric acid-lowering effects of Andrias davidianus bone peptides (ADBP) at different doses were evaluated in a mouse model of hyperuricemia induced by potassium oxonate, including 150 mg/(kg·bw), 300 mg/(kg·bw), and 600 mg/(kg·bw).Results revealed that ADBP significantly reduced the levels of uric acid (UA), creatinine (CRE), and blood urea nitrogen (BUN) in serum, and effectively suppressed the activities of xanthine oxidase (XOD) associated with UA synthesis.Furthermore, it down-regulated the expression level of XOD mRNA in the liver of hyperuricemia mice.ADBP regulated oxidative stress (total antioxidant, superoxide dismutase, glutathione peroxidase, and malondialdehyde) and inhibited pro-inflammatory cytokines (CXCL1, IL-1β, IL-6, and TNF-α), resulting in improved histopathological damage in the liver and kidneys.Studies have confirmed that ADBP had a significant uric acid-lowering effect on hyperuricemia mice and could repair long-term damage caused by high uric acid.Therefore, it can be used to relieve and treat hyperuricemia.

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