[1] 中国食品科学技术学会益生菌分会. 后生元的研究现状及产业应用[J].中国食品学报, 2022, 22(8):416-426.
Probiotics Society of the Chinese Institute of Food Science and Technology.Research of postbiotics and industrial application[J].Journal of Chinese Institute of Food Science and Technology, 2022, 22(8):416-426.
[2] SALMINEN S, COLLADO M C, ENDO A, et al.The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics[J].Nature Reviews.Gastroenterology & Hepatology, 2021, 18(9):649-667.
[3] 瞿茜楠, 兰冬雪, 黄天, 等.后生元的功能及应用研究进展[J].食品研究与开发, 2023, 44(7):6-13.
QU X N, LAN D X, HUANG T, et al.Function and application of postbiotics:A review[J].Food Research and Development, 2023, 44(7):6-13.
[4] YU Z, HAO Q, LIU S B, et al.The positive effects of postbiotic (SWF concentration©) supplemented diet on skin mucus, liver, gut health, the structure and function of gut microbiota of common carp (Cyprinus carpio) fed with high-fat diet[J].Fish & Shellfish Immunology, 2023, 135:108681.
[5] BASIR L, MOGHIMIPOUR E, SAADATZADEH A, et al.Effect of postbiotic-toothpaste on salivary levels of IgA in 6- to 12-year-old children:Study protocol for a randomized triple-blind placebo-controlled trial[J].Frontiers in Pediatrics, 2022, 10:1042973.
[6] SHEN X, XU L, ZHANG Z Q, et al.Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota[J].Frontiers in Cellular and Infection Microbiology, 2023, 13:1114364.
[7] SABAHI S, HOMAYOUNI RAD A, AGHEBATI-MALEKI L, et al.Postbiotics as the new frontier in food and pharmaceutical research[J].Critical Reviews in Food Science and Nutrition, 2023, 63(26):8375-8402.
[8] MOUSAVI GHAHFARROKHI S S, MOHAMADZADEH M, SAMADI N, et al.Management of cardiovascular diseases by short-chain fatty acid postbiotics[J].Current Nutrition Reports, 2024, 13(2):294-313.
[9] PRADHAN D, GULATI G, AVADHANI R, et al.Postbiotic Lipoteichoic acid of probiotic Lactobacillus origin ameliorates inflammation in HT-29 cells and colitis mice[J].International Journal of Biological Macromolecules, 2023, 236:123962.
[10] CHUAH W W, TAN J S, HAZWANI OSLAN S N, et al.Enhancing food preservation with postbiotic metabolites γ-aminobutyric acid (GABA) and bacteriocin-like inhibitory substances (BLIS) produced by Lactobacillus brevis C23 co-cultures in plant-based medium[J].Preparative Biochemistry & Biotechnology, 2024, 54(4):514-525.
[11] RAFIQUE N, JAN S Y, DAR A H, et al.Promising bioactivities of postbiotics:A comprehensive review[J].Journal of Agriculture and Food Research, 2023, 14:100708.
[12] IBRAHIM G A, MABROUK A M, EL-SSAYAD M F, et al.Properties of postbiotics produced by probiotics:Antimicrobial, antioxidant activities and production of vitamins, organic acids[J].2024.
[13] ROZHKOVA I V, YUROVA E A, LEONOVA V A.Evaluation of the amino acid composition and content of organic acids of complex postbiotic substances obtained on the basis of metabolites of probiotic bacteria Lacticaseibacillus paracasei ABK and Lactobacillus helveticus H9[J].Fermentation, 2023, 9(5):460.
[14] 梅欣歌. 缓解腹泻乳酸菌后生元的制备[D].南昌:南昌大学, 2024.
MEI X G.Preparation of Metazoa from lactic acid bacteria for relieving diarrhea[D].Nanchang:Nanchang University, 2024.
[15] GEORGE KERRY R, PATRA J K, GOUDA S, et al.Benefaction of probiotics for human health:A review[J].Journal of Food and Drug Analysis, 2018, 26(3):927-939.
[16] AL-HARBI N O, NADEEM A, AHMAD S F, et al.Short chain fatty acid, acetate ameliorates sepsis-induced acute kidney injury by inhibition of NADPH oxidase signaling in T cells[J].International Immunopharmacology, 2018, 58:24-31.
[17] TAHARA Y, YAMAZAKI M, SUKIGARA H, et al.Gut microbiota-derived short chain fatty acids induce circadian clock entrainment in mouse peripheral tissue[J].Scientific Reports, 2018, 8(1):1395.
[18] 何荣香, 唐红艳, 杨玲, 等.短链脂肪酸在单胃动物肠道中的生理功能及其作用机制的研究进展[J].中国畜牧杂志, 2020, 56(4):1-5.
HE R X, TANG H Y, YANG L, et al.Advances in physiological function and mechanism of short chain fatty acids in intestine of monogastric animals[J].Chinese Journal of Animal Science, 2020, 56(4):1-5.
[19] 蒙丹丽. 短链脂肪酸在肠道中的生理作用[J].中国临床新医学, 2018, 11(2):198-202.
MENG D L.Physiological function of short-chain fatty acids in the intestine[J].Chinese Journal of New Clinical Medicine, 2018, 11(2):198-202.
[20] 刘红霞, 李雪利, 吴秀英, 等.后生元研究进展及应用现状[J].食品科学, 2024, 45(1):326-333.
LIU H X, LI X L, WU X Y, et al.Progress on research and application of postbiotics[J].Food Science, 2024, 45(1):326-333.
[21] MOT,ĂT,ĂIANU A, ŞERBAN G, ANDONE S.The role of short-chain fatty acids in microbiota-gut-brain cross-talk with a focus on amyotrophic lateral sclerosis:A systematic review[J].International Journal of Molecular Sciences, 2023, 24(20):15094.
[22] LI F H, TAI L H, SUN X Y, et al.Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3[J].Cell Research, 2024, 34(4):323-326.
[23] DI W, ZHANG Y C, YI H X, et al.Research methods for structural analysis of lactic acid bacteria induced exopolysaccharides[J].Chinese Journal of Analytical Chemistry, 2018, 46(6):875-882.
[24] AL-NABULSI A A, JARADAT Z W, AL QUDSI F R, et al.Characterization and bioactive properties of exopolysaccharides produced by Streptococcus thermophilus and Lactobacillus bulgaricus isolated from labaneh[J].LWT, 2022, 167:113817.
[25] CHEN Z Z, WANG L, HE D X, et al.Exploration of the antibacterial and anti-inflammatory activity of a novel antimicrobial peptide brevinin-1BW[J].Molecules, 2024, 29(7):1534.
[26] LIU Q, WANG L, HE D X, et al.Application value of antimicrobial peptides in gastrointestinal tumors[J].International Journal of Molecular Sciences, 2023, 24(23):16718.
[27] BENÍTEZ-CHAO D F, LEÓN-BUITIMEA A, LERMA-ESCALERA J A, et al.Bacteriocins: an overview of antimicrobial, toxicity, and biosafety assessment by in vivo models[J].Frontiers in Microbiology, 2021, 12:630695.
[28] RUSSO E, GIUDICI F, FIORINDI C, et al.Immunomodulating activity and therapeutic effects of short chain fatty acids and tryptophan post-biotics in inflammatory bowel disease[J].Frontiers in Immunology, 2019, 10:2754.
[29] WU Y P, WANG Y, HU A X, et al.Lactobacillus plantarum-derived postbiotics prevent Salmonella-induced neurological dysfunctions by modulating gut-brain axis in mice[J].Frontiers in Nutrition, 2022, 9:946096.
[30] 樊欣, 彭仁.热休克蛋白70:生物学功能与作用机制研究进展[J].生命科学, 2019, 31(3):270-278.
FAN X, PENG R.Heat shock protein 70:Biological function and the mechanism for its function[J].Chinese Bulletin of Life Sciences, 2019, 31(3):270-278.
[31] BROWN S, SANTA MARIA J P Jr, WALKER S.Wall teichoic acids of gram-positive bacteria[J].Annual Review of Microbiology, 2013, 67:313-336.
[32] BALAGUER F, ENRIQUE M, LLOPIS S, et al.Lipoteichoic acid from Bifidobacterium animalis subsp.lactis BPL1:A novel postbiotic that reduces fat deposition via IGF-1 pathway[J].Microbial Biotechnology, 2022, 15(3):805-816.
[33] FRIEDRICH A D, LEONI J, PAZ M L, et al.Lipoteichoic acid from Lacticaseibacillus rhamnosus GG modulates dendritic cells and T cells in the gut[J].Nutrients, 2022, 14(3):723.
[34] 胡薇薇, 李亚琳, 全柯谕, 等.后生元缓解胃肠道疾病的研究进展及其潜在机制[J].微生物学报, 2023,63 (12):4467-4481.
HU W W, LI Y L, QUAN K Y, et al.Research progress and potential mechanism of Metazoa in relieving gastrointestinal diseases[J].China Industrial Economics, 2023,63 (12):4467-4481.
[35] NATARAJ B H, ALI S A, BEHARE P V, et al.Postbiotics-parabiotics:The new horizons in microbial biotherapy and functional foods[J].Microbial Cell Factories, 2020, 19(1):168.
[36] SICILIANO R A, LIPPOLIS R, MAZZEO M F.Proteomics for the investigation of surface-exposed proteins in probiotics[J].Frontiers in Nutrition, 2019, 6:52.
[37] DAS J K, MAHAPATRA R K, PATRO S, et al.Lactobacillus acidophilus binds to MUC3 component of cultured intestinal epithelial cells with highest affinity[J].FEMS Microbiology Letters, 2016, 363(8):fnw050.
[38] XIAO L Y, ZHANG C L, ZHANG X L, et al.Effects of Lacticaseibacillus paracasei SNB-derived postbiotic components on intestinal barrier dysfunction and composition of gut microbiota[J].Food Research International, 2024, 175:113773.
[39] MARTORELL P, ALVAREZ B, LLOPIS S, et al.Heat-treated Bifidobacterium longum CECT-7347:A whole-cell postbiotic with antioxidant, anti-inflammatory, and gut-barrier protection properties[J].Antioxidants, 2021, 10(4):536.
[40] TOUSHIK S H, KIM K, PARK S H, et al.Prophylactic efficacy of Lactobacillus curvatus B67-derived postbiotic and quercetin, separately and combined, against Listeria monocytogenes and Salmonella enterica Ser.Typhimurium on processed meat sausage[J].Meat Science, 2023, 197:109065.
[41] IZUDDIN W I, HUMAM A M, LOH T C, et al.Dietary postbiotic Lactobacillus plantarum improves serum and ruminal antioxidant activity and upregulates hepatic antioxidant enzymes and ruminal barrier function in post-weaning lambs[J].Antioxidants, 2020, 9(3):250.
[42] LOH T C, CHOE D W, FOO H L, et al.Effects of feeding different postbiotic metabolite combinations produced by Lactobacillus plantarum strains on egg quality and production performance, faecal parameters and plasma cholesterol in laying hens[J].BMC Veterinary Research, 2014, 10:149.
[43] SEO K H, LEE H G, YOUNG EOR J, et al.Effects of kefir lactic acid bacteria-derived postbiotic components on high fat diet-induced gut microbiota and obesity[J].Food Research International, 2022, 157:111445.
[44] WANG Q, LIU P F, PENG J W, et al.Postbiotic properties of exopolysaccharide produced by Levilactobacillus brevis M-10 isolated from natural fermented sour porridge through in vitro simulated digestion and fermentation[J].Journal of Food Science, 2024, 89(5):3110-3128.
[45] KIM Y, KIM H J, JI K.The proliferation inhibitory effect of postbiotics prepared from probiotics with antioxidant activity against HT-29 cells[J].Applied Sciences, 2022, 12(24):12519.
[46] HEMALATHA R, OUWEHAND A C, SAARINEN M T, et al.Effect of probiotic supplementation on total lactobacilli, bifidobacteria and short chain fatty acids in 2-5-year-old children[J].Microbial Ecology in Health and Disease, 2017, 28(1):1298340.
[47] MAGRYS′ A, PAWLIK M.Postbiotic fractions of probiotics Lactobacillus plantarum 299v and Lactobacillus rhamnosus GG show immune-modulating effects[J].Cells, 2023, 12(21):2538.
[48] CHAN M Z A, LIU S Q.Fortifying foods with synbiotic and postbiotic preparations of the probiotic yeast, Saccharomyces boulardii[J].Current Opinion in Food Science, 2022, 43:216-224.
[49] ABBASI A, RAHBAR SAADAT T, RAHBAR SAADAT Y.Microbial exopolysaccharides-β-glucans-as promising postbiotic candidates in vaccine adjuvants[J].International Journal of Biological Macromolecules, 2022, 223:346-361.
[50] OOI M F, FOO H L, LOH T C, et al.A refined medium to enhance the antimicrobial activity of postbiotic produced by Lactiplantibacillus plantarum RS5[J].Scientific Reports, 2021, 11(1):7617.
[51] CHANG H M, FOO H L, LOH T C, et al.Comparative studies of inhibitory and antioxidant activities, and organic acids compositions of postbiotics produced by probiotic Lactiplantibacillus plantarum strains isolated from Malaysian foods[J].Frontiers in Veterinary Science, 2021, 7:602280.
[52] GRIGORE-GURGU L, COTÂRLET, M, PIHUROV M, et al.Lactiplantibacillus plantarum and Lactiplantibacillus paraplantarum postbiotics:Assessment of the biotic-derived metabolites with cytocompatibility and antitumoral potential[J].Food Bioscience, 2024, 59:103863.
[53] DOMÍNGUEZ-MAQUEDA M, GARCÍA-MÁRQUEZ J, TAPIA-PANIAGUA S T, et al.Evaluation of the differential postbiotic potential of Shewanella putrefaciens Pdp11 cultured in several growing conditions[J].Marine Biotechnology, 2024, 26(1):1-18.
[54] 余萍, 汪海涛, 宋佳, 等.一种后生元工艺优化及抑菌特性的研究[J].中国微生态学杂志, 2023, 35(7):789-796.
YU P, WANG H T, SONG J, et al.Bacteriostatic characteristics and optimization of preparation process of postbiotics[J].Chinese Journal of Microecology, 2023, 35(7):789-796.
[55] DAWAN J, AHN J.Bacterial stress responses as potential targets in overcoming antibiotic resistance[J].Microorganisms, 2022, 10(7):1385.
[56] SUN Z, ZHAO Z, FANG B, et al.Effect of thermal inactivation on antioxidant, anti-inflammatory activities and chemical profile of postbiotics[J].Foods, 2023, 12(19):3579.
[57] KARBOWIAK M, GAĿEK M, SZYDĿOWSKA A, et al.The influence of the degree of thermal inactivation of probiotic lactic acid bacteria and their postbiotics on aggregation and adhesion inhibition of selected pathogens[J].Pathogens, 2022, 11(11):1260.
[58] GUIMARÃES J T, BALTHAZAR C F, SCUDINO H, et al.High-intensity ultrasound:A novel technology for the development of probiotic and prebiotic dairy products[J].Ultrasonics Sonochemistry, 2019, 57:12-21.
[59] NGUYEN T M P, LEE Y K, ZHOU W B.Effect of high intensity ultrasound on carbohydrate metabolism of bifidobacteria in milk fermentation[J].Food Chemistry, 2012, 130(4):866-874.
[60] OJHA K S, MASON T J, O’DONNELL C P, et al.Ultrasound technology for food fermentation applications[J].Ultrasonics Sonochemistry, 2017, 34:410-417.
[61] PORFIRI L, BURTSCHER J, KANGETHE R T, et al.Irradiated non-replicative lactic acid bacteria preserve metabolic activity while exhibiting diverse immune modulation[J].Frontiers in Veterinary Science, 2022, 9:859124.
[62] LIU X L, LYU X P, SUN Y, et al.Probiotic properties of Lacticaseibacillus rhamnosus grx10 revolved with complete genome[J].Food Bioscience, 2023, 51:102219.
[63] PYCLIK M, SRUTKOVA D, SCHWARZER M, et al.Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins - their chemical structure and biological attributes[J].International Journal of Biological Macromolecules, 2020, 147:333-349.
[64] LEE S Y, LEE B H, PARK J H, et al.Bifidobacterium bifidum BGN4 paraprobiotic supplementation alleviates experimental colitis by maintaining gut barrier and suppressing nuclear factor kappa B activation signaling molecules[J].Journal of Medicinal Food, 2022, 25(2):146-157.
[65] RIWES M, REDDY P.Short chain fatty acids:Postbiotics/metabolites and graft versus host disease colitis[J].Seminars in Hematology, 2020, 57(1):1-6.
[66] LIU C H, QI X F, LI D, et al.Limosilactobacillus fermentum HF06-derived paraprobiotic and postbiotic alleviate intestinal barrier damage and gut microbiota disruption in mice with ulcerative colitis[J].Journal of the Science of Food and Agriculture, 2024, 104(3):1702-1712.
[67] GAO J, LI Y B, WAN Y, et al.A novel postbiotic from Lactobacillus rhamnosus GG with a beneficial effect on intestinal barrier function[J].Frontiers in Microbiology, 2019, 10:477.
[68] 王伟, 武庆斌.益生元及后生元在儿科临床中的应用[J].中国实用儿科杂志, 2024, 39(1):47-50.
WANG W, WU Q B.Prebiotics and postbiotics in pediatric clinical application[J].Chinese Journal of Practical Pediatrics, 2024, 39(1):47-50.
[69] JASTRZĄB R, GRACZYK D, SIEDLECKI P.Molecular and cellular mechanisms influenced by postbiotics[J].International Journal of Molecular Sciences, 2021, 22(24):13475.
[70] GAO J, WANG L, JIANG J, et al.A probiotic bi-functional peptidoglycan hydrolase sheds NOD2 ligands to regulate gut homeostasis in female mice[J].Nature Communications, 2023, 14(1):3338.
[71] TEAME T, WANG A R, XIE M X, et al.Paraprobiotics and postbiotics of probiotic Lactobacilli, their positive effects on the host and action mechanisms:A review[J].Frontiers in Nutrition, 2020, 7:570344.
[72] PAVELJEK D, IVIČAK-KOCJAN K, TREVEN P, et al.Distinctive probiotic features share common TLR2-dependent signalling in intestinal epithelial cells[J].Cellular Microbiology, 2021, 23(1):e13264.
[73] LIU X F, SHAO J H, LIAO Y T, et al.Regulation of short-chain fatty acids in the immune system[J].Frontiers in Immunology, 2023, 14:1186892.
[74] MORITA N, UMEMOTO E, FUJITA S, et al.GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites[J].Nature, 2019, 566(7742):110-114.
[75] WANG G, FAN Y X, ZHANG G L, et al.Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding[J].Microbiome, 2024, 12(1):59.
[76] LAYÚS B I, GEREZ C L, RODRIGUEZ A V.Development of an ophthalmic formulation with a postbiotic of Lactiplantibacillus plantarum CRL 759[J].Beneficial Microbes, 2022, 13(5):417-426.
[77] TAVASSOLIFAR M J, VODJGANI M, SALEHI Z, et al.The influence of reactive oxygen species in the immune system and pathogenesis of multiple sclerosis[J].Autoimmune Diseases, 2020, 2020:5793817.
[78] ELD H M S, JOHNSEN P R, NIELSEN E M, et al.Soluble C-type lectin-receptor ligands stimulate ROS production in dendritic cells and potentiate killing of MRSA as well as the MRSA induced IL-12 production[J].Frontiers in Immunology, 2022, 13:845881.
[79] MONIKA M, TYAGI J S, ROKADE J J, et al.Characterization of lactic acid bacteria postbiotics & its in-vitro evaluation for antibacterial effect, anti-inflammatory and antioxidant properties[J].Indian Journal of Poultry Science, 2022, 57(3):301-308.
[80] LI S P, HENG X, GUO L Y, et al.SCFAs improve disease resistance via modulate gut microbiota, enhance immune response and increase antioxidative capacity in the host[J].Fish & Shellfish Immunology, 2022, 120:560-568.
[81] SHERWIN E, DINAN T G, CRYAN J F.Recent developments in understanding the role of the gut microbiota in brain health and disease[J].Annals of the New York Academy of Sciences, 2018, 1420(1):5-25.
[82] WANG Y Y, CHEN Y, ZHANG A L, et al.Advances in the microbial synthesis of the neurotransmitter serotonin[J].Applied Microbiology and Biotechnology, 2023, 107(15):4717-4725.
[83] QUAGEBEUR R, DALILE B, RAES J, et al.The role of short-chain fatty acids (SCFAs) in regulating stress responses, eating behavior, and nutritional state in anorexia nervosa:Protocol for a randomized controlled trial[J].Journal of Eating Disorders, 2023, 11(1):191.
[84] BYRNE C S, CHAMBERS E S, MORRISON D J, et al.The role of short chain fatty acids in appetite regulation and energy homeostasis[J].International Journal of Obesity, 2015, 39(9):1331-1338.
[85] CALDERÓN-OSPINA C A, NAVA-MESA M O.B Vitamins in the nervous system:Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin[J].CNS Neuroscience & Therapeutics, 2020, 26(1):5-13.
[86] CHUDZIK A, ORZYĿOWSKA A, ROLA R, et al.Probiotics, prebiotics and postbiotics on mitigation of depression symptoms:Modulation of the brain-gut-microbiome axis[J].Biomolecules, 2021, 11(7):1000.