食品与发酵工业 >

2025 , Vol. 51 >Issue 15: 59 - 65

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.041221

研究报告

林蛙卵油对高脂血症大鼠血脂调控的活性研究

  • 赵文萱 ,
  • 鞠志刚
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  • (贵州中医药大学 药学院,贵州 贵阳,550025)
第一作者:博士研究生,讲师(通信作者,E-mail:113613094@qq.com)

收稿日期: 2024-10-07

  修回日期: 2024-12-02

  网络出版日期: 2025-08-22

基金资助

国家重点研发计划项目(2020YFC2006002-03)

收起

Regulatory activity of Rana chensinensis ovum oil on blood lipid of hyperlipidemic rats

  • ZHAO Wenxuan ,
  • JU Zhigang
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  • (College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China)

Received date: 2024-10-07

  Revised date: 2024-12-02

  Online published: 2025-08-22

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摘要

为进一步阐释林蛙卵油的降血脂功效,该文首先构建大鼠高脂血症模型,以辛伐他汀为对照,比较不同剂量林蛙卵油灌胃给药后,对受试大鼠血清血脂水平、抗氧化因子水平、炎症因子水平、肝功能指标的影响,并对受试大鼠体重、主要脏器指数进行测算,对肝脏组织进行病理学的观察。研究结果表明,高脂血症模型构建过程中,大鼠体重显著升高(P<0.05),采用林蛙卵油干预后显著降低(P<0.05);林蛙卵油可显著降低高脂血症大鼠血清胰岛素、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α、谷草转氨酶、谷丙转氨酶、丙二醛含量(P<0.05),升高高密度脂蛋白胆固醇、超氧化物歧化酶、谷胱甘肽过氧化物酶含量(P<0.05);高脂血症大鼠肝脏和肾脏指数显著升高(P<0.05),林蛙卵油干预后显著降低(P<0.05);高脂血症大鼠肝脏组织结构重度异常,呈现弥散性脂肪变性,林蛙卵油干预后肝脏组织结构逐渐恢复。该研究表明林蛙卵油对高脂血症大鼠具有良好的血脂调控活性,必将为高脂血症的治疗提供新的思路。

关键词： 林蛙卵油; 高脂血症; 大鼠模型; 降血脂; 调控活性

本文引用格式

赵文萱 , 鞠志刚 . 林蛙卵油对高脂血症大鼠血脂调控的活性研究[J]. 食品与发酵工业, 2025 , 51(15) : 59 -65 . DOI: 10.13995/j.cnki.11-1802/ts.041221

Abstract

To further elucidate the lipid-lowering effect of Rana chensinensis ovum oil, rat model of hyperlipidemia was constructed firstly, with simvastatin as a control to compare the effect on serum lipid level, antioxidant factor level, inflammatory factor level, liver function indicator of test rats in different doses of R. chensinensis ovum oil intragastric administration.Calculated the body weight and major organ index of test rats, and observed the pathological changes of liver tissue.Results showed that during the construction of the hyperlipidemia model, there was a significant increase in rat body weight (P<0.05), while intervention by R. chensinensis ovum oil resulted in a significant decrease (P<0.05).R. chensinensis ovum oil significantly reduced the level of serum insulin, total cholesterol, triglyceride, low density lipoprotein cholesterol, IL-6, IL-1β, TNF-α,aspartate aminotransferase, alanine aminotransferase, and malondialdehyde of hyperlipidemic rats (P<0.05), and increased the level of high density lipoprotein cholesterol, superoxide dismutase, and glutathione peroxidase (P<0.05). The liver and kidney index of hyperlipidemic rats increased significantly (P<0.05), and significantly decreased after intervention by R. chensinensis ovum oil (P<0.05).The liver tissue structure of hyperlipidemic rats was severely abnormal, and showed diffuse steatosis.After intervention by R. chensinensis ovum oil, the liver tissue structure gradually returned.The study indicated that R. chensinensis ovum oil has well blood lipid regulation activity on hyperlipidemic rats, which will provide new ideas for the treatment of hyperlipidemia.

Key words： Rana chensinensis ovum oil; hyperlipidemia; rat model; hypolipidemic; regulatory activity

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