[1] TÄUBER S, GRÜNBERGER A.Microfluidic single-cell scale-down systems:Introduction, application, and future challenges[J].Current Opinion in Biotechnology, 2023, 81:102915.
[2] SARTAS M, SCHUT M, PROIETTI C, et al.Scaling Readiness:Science and practice of an approach to enhance impact of research for development[J].Agricultural Systems, 2020, 183:102874.
[3] DELVIGNE F, TAKORS R, MUDDE R, et al.Bioprocess scale-up/down as integrative enabling technology:From fluid mechanics to systems biology and beyond[J].Microbial Biotechnology, 2017, 10(5):1267-1274.
[4] TAJSOLEIMAN T, MEARS L, KRÜHNE U, et al.An industrial perspective on scale-down challenges using miniaturized bioreactors[J].Trends in Biotechnology, 2019, 37(7):697-706.
[5] FARRELL P, SUN J, GAO M, et al.Development of a scaled-down aerobic fermentation model for scale-up in recombinant protein vaccine manufacturing[J].Vaccine, 2012, 30(38):5695-5698.
[6] HARINGA C, DESHMUKH A T, MUDDE R F, et al.Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S.cerevisiae fermentation[J].Chemical Engineering Science, 2017, 170:653-669.
[7] HUANG R J, WANG K, FLAMM M H, et al.Development and qualification of 3 L scale-down model for large scale vaccine process on Vero cell culture using microcarriers[J].Biotechnology and Bioengineering, 2024, 121(11):3402-3414.
[8] JIN G Y, ZHU Y, XU Y.Mystery behind Chinese liquor fermentation[J].Trends in Food Science & Technology, 2017, 63:18-28.
[9] ZHUANSUN W W, XU J, LI Z Q, et al.Dynamic changes in the microbial community, flavour components in Jiupei of a novel Maotai-Luzhou-flavoured liquor under various daqu blending modes and their correlation analysis[J].LWT, 2022, 172:114167.
[10] 赵玉杰, 靳光远, 唐群勇, 等.基于热量平衡模型的大曲发酵升温机理研究[J].食品与发酵工业, 2024, 50(14):18-25.
ZHAO Y J, JIN G Y, TANG Q Y, et al.The mechanism of heat transfer during Daqu fermentation based on heat balance modeling[J].Food and Fermentation Industries, 2024, 50(14):18-25.
[11] JIN G Y, UHL P, ZHU Y, et al.Modeling of industrial-scale anaerobic solid-state fermentation for Chinese liquor production[J].Chemical Engineering Journal, 2020, 394:124942.
[12] JIN G Y, ZHAO Y J, XIN S H, et al.Solid-state fermentation engineering of traditional Chinese fermented food[J].Foods, 2024, 13(18):3003.
[13] PETIOT C, DE GUARDIA A.Composting in a laboratory reactor:A review[J].Compost Science & Utilization, 2004, 12(1):69-79.
[14] WANG Y J, PANG L, LIU X Y, et al.Using thermal balance model to determine optimal reactor volume and insulation material needed in a laboratory-scale composting reactor[J].Bioresource Technology, 2016, 206:164-172.
[15] TIKHOMIROVA T S, TARASKEVICH M S, PONOMARENKO O V.The role of laboratory-scale bioreactors at the semi-continuous and continuous microbiological and biotechnological processes[J].Applied Microbiology and Biotechnology, 2018, 102(17):7293-7308.
[16] WANG G, XU X C, ZHOU L, et al.A pilot-scale study on the start-up of partial nitrification-anammox process for anaerobic sludge digester liquor treatment[J].Bioresource Technology, 2017, 241:181-189.
[17] WANG G, WU B F, ZHAO J F, et al.Power input effects on degeneration in prolonged penicillin chemostat cultures:A systems analysis at flux, residual glucose, metabolite, and transcript levels[J].Biotechnology and Bioengineering, 2018, 115(1):114-125.
[18] ENGINEERTOOLBOX.https://www.engineeringtoolbox.com/[Z].2001
[19] JIANG Z M, CHEN Y, WANG D L, et al.The influence of porosity of the grain medium on the flavour formation of Chinese liquor during solid-state fermentation[J].Journal of the Institute of Brewing, 2016, 122(3):468-472.
[20] LIU S Q, SKINNER-NEMEC K A, LEATHERS T D.Lactobacillus buchneri strain NRRL B-30929 converts a concentrated mixture of xylose and glucose into ethanol and other products[J].Journal of Industrial Microbiology & Biotechnology, 2008, 35(2):75-81.
[21] HAO M J, WU D, XU Y, et al.A novel endo-polygalacturonase from Penicillium rolfsii with prebiotics production potential:Cloning, characterization and application[J].Foods, 2022, 11(21):3469.
[22] WANG S L, XIONG W, WANG Y Q, et al.Temperature-induced annual variation in microbial community changes and resulting metabolome shifts in a controlled fermentation system[J].mSystems, 2020, 5(4):e00555-20.
[23] WU Q, ZHU Y, FANG C, et al.Can we control microbiota in spontaneous food fermentation? —Chinese liquor as a case example[J].Trends in Food Science & Technology, 2021, 110:321-331.
[24] VAURIS A, VALCAUDA S, HUSSON F, et al.A novel method to assess heat transfer and impact of relevant physicochemical parameters for the scaling up of solid state fermentation systems[J].Biotechnology Reports, 2022, 36:e00764.
[25] MARTÍNEZ-ESPINOSA R M.Molecular advances in microbial metabolism 2.0[J].International Journal of Molecular Sciences, 2024, 25(2):1361.
[26] REN Z Q, CHEN Q X, TANG T X, et al.Unraveling the water source and formation process of Huangshui in solid-state fermentation[J].Food Science and Biotechnology, 2025, 34(3):665-675.
[27] SAARNI A, MILLER K V, BLOCK D E.A multi-parameter, predictive model of starch hydrolysis in barley beer mashes[J].Beverages, 2020, 6(4):60.
[28] RECEK N, ZHOU R W, ZHOU R S, et al.Improved fermentation efficiency of S.cerevisiae by changing glycolytic metabolic pathways with plasma agitation[J].Scientific Reports, 2018, 8(1):8252.
[29] CHEN C, XIONG Y, XIE Y H, et al.Metabolic characteristics of lactic acid bacteria and interaction with yeast isolated from light-flavor Baijiu fermentation[J].Food Bioscience, 2022, 50:102102.
[30] HUANG Y H, YI Z L, JIN Y L, et al.New microbial resource:Microbial diversity, function and dynamics in Chinese liquor starter[J].Scientific Reports, 2017, 7:14577.
[31] XUE T D, ZHANG J H, WANG T R, et al.Reveal the microbial communities and functional prediction during the fermentation of Fen-flavor Baijiu via metagenome combining amplicon sequencing[J].Annals of Microbiology, 2023, 73(1):16.
[32] 王雪山, 杜海, 徐岩.清香型白酒发酵过程中微生物种群空间分布[J].食品与发酵工业, 2018, 44(9):1-8.
WANG X S, DU H, XU Y.Spatial distribution of microbial community during Chinese light-flavor liquor fermentation[J].Food and Fermentation Industries, 2018, 44(9):1-8.
[33] WANG H Y, XU Y.Microbial succession and metabolite changes during the fermentation of Chinese light aroma-style liquor[J].Journal of the Institute of Brewing, 2019, 125(1):162-170.
[34] WANG H Y, GAO Y B, FAN Q W, et al.Characterization and comparison of microbial community of different typical Chinese liquor Daqus by PCR-DGGE[J].Letters in Applied Microbiology, 2011, 53(2):134-140.
[35] WANG H Y, XU Y.Effect of temperature on microbial composition of starter culture for Chinese light aroma style liquor fermentation[J].Letters in Applied Microbiology, 2015, 60(1):85-91.
[36] PANG X N, HAN B Z, HUANG X N, et al.Effect of the environment microbiota on the flavour of light-flavour Baijiu during spontaneous fermentation[J].Scientific Reports, 2018, 8:3396.
[37] WANG L L, WU L, XIANG D H, et al.Characterization of key aroma compounds in aged Qingxiangxing Baijiu by comparative aroma extract dilution analysis, quantitative measurements, aroma recombination, and omission studies[J].Food Chemistry, 2023, 419:136027.