研究报告

糙米酵素调节肠道健康的功效评价及其作用机制

  • 孟繁桐 ,
  • 王默涵 ,
  • 马喜山 ,
  • 张璐 ,
  • 曹秋阁 ,
  • 郝曦煜 ,
  • 刘士伟 ,
  • 郑骁阳 ,
  • 苑鹏 ,
  • 王雪 ,
  • 柳嘉
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  • 1(黑龙江北纬四十七植物蛋白有限公司,黑龙江 齐齐哈尔,161002)
    2(中国食品发酵工业研究院有限公司,北京,100015)
第一作者:硕士,中级工程师(王雪正高级工程师和柳嘉正高级工程师为共同通信作者,E-mail:wangxue1@feihe.com;E-mail:liujiajessica@163.com)

收稿日期: 2024-09-02

  修回日期: 2025-01-13

  网络出版日期: 2025-10-16

Effect evaluation of brown rice ferments on intestinal health and its mechanism

  • MENG Fantong ,
  • WANG Mohan ,
  • MA Xishan ,
  • ZHANG Lu ,
  • CAO Qiuge ,
  • HAO Xiyu ,
  • LIU Shiwei ,
  • ZHENG Xiaoyang ,
  • YUAN Peng ,
  • WANG Xue ,
  • LIU Jia
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  • 1(Heilongjiang Beiwei 47 Plant Protein Co., Ltd., Qiqihar 161002, China)
    2(China National Research Institute of Food and Fermentation Industries Co.Ltd., Beijing 100015, China)

Received date: 2024-09-02

  Revised date: 2025-01-13

  Online published: 2025-10-16

摘要

为探究糙米酵素对肠道健康的调节作用及其作用机制,该文基于非靶向代谢组学、斑马鱼便秘模型、体外模拟结肠厌氧发酵,挖掘糙米经过发酵处理后对肠道健康可能有益的潜在功能物质,探究糙米酵素改善肠道运动的机制机理,评价糙米酵素对人体肠道微生物组成和结构特征的影响。结果表明,糙米经过发酵处理后代谢差异显著(P<0.05),存在改善肠道健康的潜在功能物质,可通过下调斑马鱼nos1nos2anos2b基因的表达,提高便秘斑马鱼一氧化氮的清除率,从而有效促进斑马鱼的肠道运动,还可通过调节人体肠道菌群的组成结构丰富人体肠道微生物组成。因此糙米酵素对肠道健康具有积极作用,是一种有前途的饮食干预策略。

本文引用格式

孟繁桐 , 王默涵 , 马喜山 , 张璐 , 曹秋阁 , 郝曦煜 , 刘士伟 , 郑骁阳 , 苑鹏 , 王雪 , 柳嘉 . 糙米酵素调节肠道健康的功效评价及其作用机制[J]. 食品与发酵工业, 2025 , 51(18) : 304 -312 . DOI: 10.13995/j.cnki.11-1802/ts.040936

Abstract

This study explored the regulatory effect of brown rice ferments on intestinal health and its mechanism based on non-targeted metabolomics, zebrafish constipation model, and in vitro simulated colon anaerobic fermentation, to find the potential functional substances that might be beneficial to intestinal health after fermentation of brown rice and the mechanism to improve intestinal motility.Then, the study evaluated the effects of brown rice ferments on the composition and structure of human intestinal microorganisms.Results showed that there were significant differences in the metabolism of brown rice after fermentation treatment (P<0.05), and there were potential functional substances to improve intestinal health.By down-regulating the expressions of nos1, nos2a, and nos2b genes in constipated zebrafish, brown rice ferments could increase the clearance rate of nitric oxidein, thus effectively promoting the intestinal motility of zebrafish.By regulating the composition structure of human intestinal flora, brown rice ferments could enrich the composition of human intestinal microbes.Therefore, brown rice ferments have a positive effect on intestinal health and will be a promising dietary intervention strategy.

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