食品与发酵工业 >

2025 , Vol. 51 >Issue 22: 154 - 162

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.042294

研究报告

羊栖菜多酚提取物对慢性不可预知温和应激小鼠抑郁症状的缓解作用

  • 张煜 ,
  • 任青兮 ,
  • 刘双平 ,
  • 李美英 ,
  • 毛健
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  • 1(华南农业大学 食品学院,广东 广州,510642)
    2(南方海洋科学与工程广东省实验室(广州),广东 广州,511458)
    3(海洋生物资源高值化利用与装备开发广东省工程研究中心,广东 广州,511458)
    4(江南大学 食品学院,江苏 无锡,214122)
第一作者:硕士研究生(李美英副教授和毛健教授为共同通信作者,E-mail:lmy1982@scau.edu.cn;maojian@jiangnan.edu.cn)

收稿日期: 2025-02-17

  修回日期: 2025-04-05

  网络出版日期: 2025-12-15

基金资助

南方海洋科学与工程广东省实验室(广州)人才队伍经费项目(GML2021GD0806);江苏省自然科学基金青年基金项目(BK20221075);国家自然科学基金青年基金项目(32202025)

收起

The alleviating effect of Sargassum fusiforme polyphenol extract on depressive symptoms in mice under chronic unpredictable mild stress

  • ZHANG Yu ,
  • REN Qingxi ,
  • LIU Shuangping ,
  • LI Meiying ,
  • MAO Jian
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  • 1(College of Food Science, South China Agricultural University, Guangzhou 510642, China)
    2(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China)
    3(Guangdong Engineering Research Center of High-Value Utilization and Equipment Development of Marine Biological Resources, Guangzhou 511458, China)
    4(School of Food Sciences and Technology, Jiangnan University, Wuxi 214122, China)

Received date: 2025-02-17

  Revised date: 2025-04-05

  Online published: 2025-12-15

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摘要

该文旨在探究羊栖菜多酚提取物(Sargassum fusiforme polyphenol extract,SFP)对小鼠抑郁症状的缓解作用及其作用机制。采用慢性不可预知温和应激(chronic unpredictable mild stress,CUMS)的方法构建C57BL/6 J小鼠抑郁模型,通过设置不同剂量SFP干预组,系统评估其对模型小鼠体重变化、行为学特征、神经递质水平、下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴功能、炎症因子表达及海马组织病理学的影响。与空白组相比,模型组小鼠体重显著降低(P<0.05),并在糖水偏好等行为学实验中表现出抑郁行为。同时,模型组小鼠海马体齿状回(dentate gyrus,DG)区神经元数量、五羟色胺(5-hydroxy tryptamine,5-HT)等神经递质含量以及IL-10等抗炎因子水平显著降低(P<0.05);此外,HPA轴相关激素水平和IL-1β等促炎因子含量显著升高(P<0.05);SFP干预后上述指标均得以逆转,且呈剂量依赖性。SFP可能通过缓解HPA轴亢奋、修复受损海马神经元、调节神经递质和炎症水平等多种途径,综合发挥抗抑郁作用。该研究拓展了抗抑郁领域,为海洋藻类资源在功能性食品和健康产业中的高值化开发利用提供了新方向。

关键词： 羊栖菜多酚提取物; 抑郁; 慢性不可预知温和应激; 神经递质; 炎症; 下丘脑-垂体-肾上腺轴

本文引用格式

张煜 , 任青兮 , 刘双平 , 李美英 , 毛健 . 羊栖菜多酚提取物对慢性不可预知温和应激小鼠抑郁症状的缓解作用[J]. 食品与发酵工业, 2025 , 51(22) : 154 -162 . DOI: 10.13995/j.cnki.11-1802/ts.042294

Abstract

This study aimed to investigate the antidepressant effects of Sargassum fusiforme polyphenol extract (SFP) and its underlying mechanisms.A chronic unpredictable mild stress (CUMS) model was established in C57BL/6 J mice to induce depression-like behaviors.Mice were then administered varying doses of SFP to systematically evaluate its effects on body weight, behavioral performance, neurotransmitter levels, hypothalamic-pituitary-adrenal (HPA) axis function, inflammatory cytokine expression, and hippocampal histopathology.Compared with the control group, the CUMS group exhibited a significant reduction in body weight (P<0.05) and depressive-like behaviors in tests such as the sucrose preference test.Furthermore, the CUMS group showed a marked decrease in the number of neurons in the hippocampal dentate gyrus (DG) region, levels of neurotransmitters such as 5-hydroxytryptamine (5-HT), and levels of anti-inflammatory factors such as interleukin-10 (P<0.05).Concurrently, there was a significant increase in HPA axis-related hormones and pro-inflammatory factors such as interleukin-1 beta (P<0.05).SFP intervention reversed these abnormalities in a dose-dependent manner.Mechanistically, SFP may exert its antidepressant effects through multiple pathways, including alleviating HPA axis hyperactivity, repairing damaged hippocampal neurons, and regulating neurotransmitter and inflammation levels.This study expands the field of antidepression and provides a new direction for the high-value development and utilization of marine algae resources in functional foods and the health industry.

Key words： Sargassum fusiforme polyphenol extract; depression; chronic unpredictable mild stress; neurotransmitters; inflammation; hypothalamic-pituitary-adrenal axis

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