食品与发酵工业 >

2025 , Vol. 51 >Issue 23: 363 - 370

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.042572

综述与专题评论

蜡样芽胞杆菌生物被膜与呕吐毒素cereulide的研究进展

  • 任凡冲 ,
  • 刘阳泰 ,
  • 王晔茹 ,
  • 杨雪风 ,
  • 乔霖楠 ,
  • 刘洋 ,
  • 余睿婕 ,
  • 艾克旦·托呼提 ,
  • 董庆利
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  • 1(上海理工大学 健康科学与工程学院,上海,200093)
    2(国家食品安全风险评估中心,北京,100022)
    3(国家市场监督管理总局重点实验室(乳及乳制品检测与监控技术),上海市质量监督检验技术研究院,上海,200233)
第一作者:硕士研究生(董庆利教授为通信作者,E-mail:dongqingli@126.com)

收稿日期: 2025-03-01

  修回日期: 2025-03-21

  网络出版日期: 2025-12-25

基金资助

2024—2026年国家食品安全优先风险评估项目;乳业生物技术国家重点实验室开放课题项目(SKLDB2024-003)

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Research progress on biofilm and cereulide in Bacillus cereus

  • REN Fanchong ,
  • LIU Yangtai ,
  • WANG Yeru ,
  • YANG Xuefeng ,
  • QIAO Linnan ,
  • LIU Yang ,
  • YU Ruijie ,
  • AIKEDAN Tuohuti ,
  • DONG Qingli
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  • 1(School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)
    2(China National Center for Food Safety Risk Assessment, Beijing 100022, China)
    3(Key Laboratory of Milk and Dairy Products Detection and Monitoring Technology, State Administration for Market Regulation, Shanghai Institute of Quality Inspection and Technical Research, Shanghai 200233, China)

Received date: 2025-03-01

  Revised date: 2025-03-21

  Online published: 2025-12-25

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摘要

蜡样芽胞杆菌(Bacillus cereus)作为一种重要的食源性致病菌,通过孢子及生物被膜在食品加工环境中长期存留,引发呕吐型毒素(cereulide)和腹泻型毒素中毒。蜡样芽胞杆菌这一特性对食品的生产加工环境和人类健康带来了重大隐患。该文对蜡样芽胞杆菌生物被膜与cereulide的相关研究进展进行了系统阐述。文章讨论了蜡样芽胞杆菌生物被膜与cereulide形成的影响因素及其两者之间的相互影响,分析并归纳了关于蜡样芽胞杆菌菌体和cereulide的检测方法,进一步阐述了蜡样芽胞杆菌生物被膜与cereulide的相关清除研究。蜡样芽胞杆菌生物被膜与cereulide之间联系是未来呕吐型蜡样芽胞杆菌研究的必要方向,蜡样芽胞杆菌相关检测与清除方法的研究仍具有巨大潜力。该综述旨在对蜡样芽胞杆菌的风险防控研究提供重要参考。

关键词： 蜡样芽胞杆菌; 生物被膜; 呕吐型毒素(cereulide); 形成; 检测; 清除

本文引用格式

任凡冲 , 刘阳泰 , 王晔茹 , 杨雪风 , 乔霖楠 , 刘洋 , 余睿婕 , 艾克旦·托呼提 , 董庆利 . 蜡样芽胞杆菌生物被膜与呕吐毒素cereulide的研究进展[J]. 食品与发酵工业, 2025 , 51(23) : 363 -370 . DOI: 10.13995/j.cnki.11-1802/ts.042572

Abstract

Bacillus cereus, as a significant foodborne pathogen, persists in food processing environments through spores and biofilms, causing cereulide and enterotoxin poisoning.The ability of B.cereus to form spores and biofilms poses significant risks to food safety and human health.This article discusses the factors influencing B.cereus biofilm formation and cereulide synthesis, as well as their bidirectional interactions.It analyzes and summarizes detection methods for both bacterial cells and cereulide, and further explores strategies for eliminating B.cereus biofilms and cereulide.The interplay between B.cereus biofilms and cereulide production represents a critical direction for future research on emetic B.cereus strains.Furthermore, studies on detection and removal methods for B.cereus and its cereulide remain areas of substantial potential.This review aims to provide critical insights for advancing risk prevention and control strategies against B.cereus.

Key words： Bacillus cereus; biofilm; cereulide; formation; detection; removal

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