[1] 薛紫鲸, 张丹, 郭龙, 等.经典名方中苦杏仁的本草考证[J].中国实验方剂学杂志, 2022, 28(10):207-214.
XUE Z J, ZHANG D, GUO L, et al. Herbal textual research on bitter almond in classic prescriptions. Chinese Journal of Experimental Traditional Medical Formulae, 2022, 28(10):207-214.
[2] 吴月亮, 许淼, 董胜君, 等.不同产区苦杏仁营养成分分析[J].食品工业科技, 2019, 40(23):300-305.
WU Y L,XU M,DONG S J,et al.Analysis of nutritional composition of bitter almond from different growing areas[J].Science and Technology of Food Industry, 2019, 40(23):300-305.
[3] NING C, JIAO Y H, WANG J Q, et al.Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances[J].Food Science and Human Wellness, 2022, 11(5):1121-1133.
[4] CHATTOPADHYAY R, CHATTOPADHYAY R N, NANDY A, et al.Preliminary report on antihyperglycemic effect of a fraction of fresh leaves of Azadirachta indica (Beng.Neem)[J].Bulletin of the Calcutta School of Tropical Medicine, 1987, 35(2):29-33.
[5] LI W L, ZHENG H C, BUKURU J, et al.Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus[J].Journal of Ethnopharmacology, 2004, 92(1):1-21.
[6] ONG K L, STAFFORD L K, MCLAUGHLIN S A, et al.Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050:A systematic analysis for the Global Burden of Disease Study 2021[J].Lancet, 2023, 402(10397):203-234.
[7] 王海东. 五味子蛋白肽的制备和生物活性研究[D].长春:长春中医药大学, 2023.
WANG H D.Study on preparation and biological activity of Sehizandrae chinensis protein peptide[D].Changchun:Changchun University of Chinese Medicine, 2023.
[8] 张晓艺, 王晗, 裴栋, 等.食品蛋白来源的降血糖肽的研究进展[J].生物技术, 2022, 32(4):528-535;505.
ZHANG X Y, WANG H, PEI D,et al.Research progress of hypoglycemic peptides derived from food protein[J].Biotechnology, 2022, 32(4):528-535;505.
[9] 柯志强, 马倩倩, 李丹, 等.GLP-1受体激动剂对心血管作用的研究进展[J].中国药理学通报, 2024, 40(3):426-430.
KE Z Q,MA Q Q,LI D,et al.Advances on cardiovascular effects of GLP-1RAs[J].Chinese Pharmacological Bulletin,2024, 40(3):426-430.
[10] 郑彩云, 林妹妹, 戴亨纷.GLP-1受体激动剂致2型糖尿病患者胃肠道不良反应的网状Meta分析[J].中国新药与临床杂志, 2024, 43(6):460-468.
ZHENG C Y,LIN M M,DAI H F.GLP-1 receptor agonists cause gastrointestinal adverse reaction in patients with type 2 diabetes mellitus:A network meta-analysis[J].Chinese Journal of New Drugs and Clinical Remedies, 2024, 43(6):460-468.
[11] YUAN X, LI P C, XIAO Z W, et al.Preparation and identification of hypoglycemic bioactive peptide from Amygdalus communis L.by multienzyme hydrolysis[J].Process Biochemistry, 2024, 136:292-300.
[12] 丛之慧. 基于虚拟筛选杏仁降糖肽及纳米包埋技术研究[D].重庆:重庆三峡学院,2023.
CONG Z H.Research on virtual screening of hypoglycemic peptides from almonds and nanoparticle encapsulation technology[D].Chongqing:Chongqing Three Gorges University, 2023.
[13] 王晟. 山杏(Armeniaca sibirica)仁蛋白辅助降血糖饮料开发[D].北京:北京林业大学, 2014.
WANG S.Development of antidiabetic beverage from apricot (Armeniaca sibirica) kernel protein[D].Beijing:Beijing Forestry University, 2014.
[14] 武安琪. 基于苦杏仁醇溶蛋白的降血糖肽饮料制备工艺研究[D].乌鲁木齐:新疆农业大学, 2021.
WU A Q.Preparation of a bitter almond kernel prolamin based hypoglycemic peptide drink[D].Urumqi:Xinjiang Agricultural University, 2021.
[15] 刘雪峰. 酶解杏仁蛋白制备活性多肽及其降血糖功能研究[D].呼和浩特:内蒙古农业大学,2010.
LIU X F.Study on preparation of polypeptides by enzymolysis almond protein and their reducing blood glucose effectives[D].Hohhot:Inner Mongolia Agricultural University, 2010.
[16] 李志洲,刘军海.甜杏仁有效成份分析及多糖的体外抗氧化性研究[J].氨基酸和生物资源,2008,30(4):34-36;41.
LI Z Z,LIU J H.Study on composition and property of anti-oxidization of polysaccharides in sweet almond[J].Amino Acids & Biotic Resources, 2008,30(4):34-36;41.
[17] 彭妍琦. 杏仁多糖的结构表征及其改善溃疡性结肠炎的机制研究[D].沈阳:沈阳农业大学,2024.
PEMG Y Q.Structural characterization of almond polysaccharides and their mechanism of amelioration of ulcerative colitis[D].Shenyang:Shenyang Agricultural University, 2024.
[18] PENG Y Q, ZHANG Z H, CHEN W Y, et al.Structural characterization, α-glucosidase inhibitory activity and antioxidant activity of neutral polysaccharide from apricot(Armeniaca Sibirica L.Lam) kernels[J].International Journal of Biological Macromolecules, 2023, 238:124109.
[19] 雷甜甜. 苦杏仁苷抑制LDLR-/-小鼠动脉粥样硬化的作用及机制研究[D].成都:电子科技大学,2020.
LEI T T.The inhibiting effect and possible mechanisms of amygdalin on atherosclerosis in LDL receptor-deficient mice[D].Chengdu:University of Electronic Science and Technology of China, 2020.
[20] 吕建珍, 邓家刚.苦杏仁苷的药理作用研究进展[J].现代药物与临床, 2012, 27(5):530-535.
LV J Z,DENG J G.Research progress in pharmacological effects of amygdalin[J].Drugs & Clinic, 2012,27(5):530-535.
[21] 李彦灵. 苦杏仁降血脂部位筛选及质量标准制定[D].广州:广州中医药大学,2013.
LI Y L.Selecting the hypolipidemic parts of armeniacae semen and studying on its quality standard[D].Guangzhou:Guangzhou University of Chinese Medicine, 2013.
[22] CHEN J W, HU Y B, MOU X, et al.Amygdalin alleviates renal injury by suppressing inflammation, oxidative stress and fibrosis in streptozotocin-induced diabetic rats[J].Life Sciences, 2021, 265:118835.
[23] LI S Y, LU S H, WANG L, et al.Effects of amygdalin on ferroptosis and oxidative stress in diabetic retinopathy progression via the NRF2/ARE signaling pathway[J].Experimental Eye Research, 2023, 234:109569.
[24] 闫萌萌, 徐林丽, 刘岩岩, 等.苦杏仁苷对糖尿病肾病大鼠肾小管上皮细胞损伤的影响[J].中国临床药理学杂志, 2024, 40(7):1019-1023.
YAN M M,XU L L,LIU Y Y,et al.Effects of amygdalin on renal tubular epithelial cell injury in diabetes nephropathy rats[J].The Chinese Journal of Clinical Pharmacology, 2024, 40(7):1019-1023.
[25] HEIKKILA R E, CABBAT F S.The prevention of alloxan-induced diabetes by amygdalin[J].Life Sciences,1980,27(8):659-662.
[26] 黄首瑜, 方忠雪, 孙长海, 等. 苦杏仁皮多聚多酚的结构研究. 沈阳药科大学学报, 2025, 42(6):578-585.
HUANG S Y, FANG Z X, SUN C H, et al. Compositional characterization of polymeric polyphenols from bitter almond skins. Journal of Shenyang Pharmaceutical University, 2025, 42(6):578-585.
[27] BOLLING B W.Almond polyphenols:Methods of analysis, contribution to food quality, and health promotion[J].Comprehensive Reviews in Food Science and Food Safety, 2017, 16(3):346-368.
[28] TSUJITA T, SHINTANI T, SATO H.α-Amylase inhibitory activity from nut seed skin polyphenols.1.Purification and characterization of almond seed skin polyphenols[J].Journal of Agricultural and Food Chemistry, 2013, 61(19):4570-4576.
[29] BEN KHADHER T, SASSI-AYDI S, AYDI S, et al.Phytochemical profiling and biological potential of Prunus dulcis shell extracts[J].Plants, 2023, 12(14):2733.
[30] KUMAR V, SACHAN R, RAHMAN M, et al.Prunus amygdalus extract exert antidiabetic effect via inhibition of DPP-IV:In-silico and In-vivo approaches[J].Journal of Biomolecular Structure and Dynamics, 2021, 39(11):4160-4174.
[31] BROWN R, WARE L, GRAY A R, et al.Snacking on almonds lowers glycaemia and energy intake compared to a popular high-carbohydrate snack food:An acute randomised crossover study[J].International Journal of Environmental Research and Public Health, 2021, 18(20):10989.
[32] GULATI S, MISRA A, PANDEY R M.Effect of almond supplementation on glycemia and cardiovascular risk factors in Asian Indians in north India with type 2 diabetes mellitus:A 24-week study[J].Metabolic Syndrome and Related Disorders, 2017, 15(2):98-105.
[33] GULATI S, MISRA A, TIWARI R, et al.Beneficial effects of premeal almond load on glucose profile on oral glucose tolerance and continuous glucose monitoring:Randomized crossover trials in Asian Indians with prediabetes[J].European Journal of Clinical Nutrition, 2023, 77(5):586-595.
[34] LI S C, LIU Y H, LIU J F, et al.Almond consumption improved glycemic control and lipid profiles in patients with type 2 diabetes mellitus[J].Metabolism, 2011, 60(4):474-479.
[35] BOWEN J, LUSCOMBE-MARSH N D, STONEHOUSE W, et al.Effects of almond consumption on metabolic function and liver fat in overweight and obese adults with elevated fasting blood glucose:A randomised controlled trial[J].Clinical Nutrition ESPEN, 2019, 30:10-18.
[36] CROUCH M A, SLATER R T 3rd.Almond “appetizer” effect on glucose tolerance test (GTT) results[J].Journal of the American Board of Family Medicine, 2016, 29(6):759-766.
[37] VIGUILIOUK E, KENDALL C W C, BLANCO MEJIA S, et al.Effect of tree nuts on glycemic control in diabetes:A systematic review and meta-analysis of randomized controlled dietary trials[J].PLoS One, 2014, 9(7):e103376.
[38] YU Z, MALIK V S, KEUM N, et al.Associations between nut consumption and inflammatory biomarkers[J].The American Journal of Clinical Nutrition, 2016, 104(3):722-728.
[39] TINDALL A M, JOHNSTON E A, KRIS-ETHERTON P M, et al.The effect of nuts on markers of glycemic control:A systematic review and meta-analysis of randomized controlled trials[J].The American Journal of Clinical Nutrition, 2019, 109(2):297-314.
[40] 王丽丽. 不同种类坚果对2型糖尿病患者血糖控制的影响[D].苏州:苏州大学,2017.
WANG L L.Effect of different types of nuts on glycemic control in patients with type 2 diabetes mellitus[D].Suzhou:Soochow University, 2017.
[41] HOU Y Y, OJO O, WANG L L, et al.A randomized controlled trial to compare the effect of peanuts and almonds on the cardio-metabolic and inflammatory parameters in patients with type 2 diabetes mellitus[J].Nutrients, 2018, 10(11):1565.
[42] ZENG X Q, ZHANG C M, TONG M L, et al.Knockdown of NYGGF4 increases glucose transport in C2C12 mice skeletal myocytes by activation IRS-1/PI3K/AKT insulin pathway[J].Journal of Bioenergetics and Biomembranes, 2012, 44(3):351-355.
[43] 苏通.番石榴叶对2型糖尿病db/db小鼠肝脏PI3K/AKT信号通路的影响探究[D].北京:北京中医药大学,2023.
SU T.Investigation of the Effect of Psidium guajava leaves on the PI3K/AKT signaling pathway in the liver of type 2 diabetic db/db mice[D].Beijing:Beijing University of Chinese Medicine, 2023.
[44] 韩金承.苦杏仁油提取、抗氧化活性及微胶囊制备研究[D].锦州:锦州医科大学, 2023.
HAN J C.Study on extraction, antioxidant activity and micro-capsule preparation of bitter almond oil [D].Jinzhou:Jinzhou Medical University, 2023.
[45] GAO Y, LI C, CHEN B, et al.Anti-hyperlipidemia and antioxidant activities of Amygdalus pedunculata seed oil[J].Food & Function, 2016, 7(12):5018-5024.
[46] 陈默.珍珠油杏杏仁蛋白和抗氧化肽的制备及功能活性研究[D].泰安:山东农业大学,2022.
CHEN M.Preparation and functional activity of almond protein and antioxidant peptides from Zhenzhuyou apricot [D].Tai'an:Shandong Agricultural University, 2022.
[47] 刘蕊. 杏仁油对Ⅰ型糖尿病大鼠的保护作用及机制研究[D].保定:河北农业大学, 2021.
LIU R.Study on the protective effect and mechanism of almond oil on type I diabetic rats[D].Baoding:Hebei Agricultural University, 2021.
[48] SU M, HU R, TANG T, et al.Review of the correlation between Chinese medicine and intestinal microbiota on the efficacy of diabetes mellitus[J].Frontiers in Endocrinology, 2022, 13:1085092.
[49] OJO O, WANG X H, OJO O O, et al.The effects of almonds on gut microbiota, glycometabolism, and inflammatory markers in patients with type 2 diabetes:A systematic review and meta-analysis of randomised controlled trials[J].Nutrients, 2021, 13(10):3377.
[50] REN M X, ZHANG H Y, QI J D, et al.An almond-based low carbohydrate diet improves depression and glycometabolism in patients with type 2 diabetes through modulating gut microbiota and GLP-1:A randomized controlled trial[J].Nutrients, 2020, 12(10):3036.
[51] ZHAO L P, ZHANG F, DING X Y, et al.Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J].Science, 2018, 359(6380):1151-1156.
[52] 胡安妮. 基于杏仁的低碳水化合物饮食方案应用于2型糖尿病患者的可行性分析及降糖机制探索[D].苏州:苏州大学,2020.
HU A N.Feasibility of low carbohydrate diet based on almonds applied to type 2 diabetes mellitus and its mechanism of hypoglycemic effect[D].Suzhou:Soochow University, 2020.
[53] CRACIUN C I, NEAG M A, CATINEAN A, et al.The relationships between gut microbiota and diabetes mellitus, and treatments for diabetes mellitus[J].Biomedicines, 2022, 10(2):308.
[54] CHOO J M, TRAN C D, LUSCOMBE-MARSH N D, et al.Almond consumption affects fecal microbiota composition, stool pH, and stool moisture in overweight and obese adults with elevated fasting blood glucose:A randomized controlled trial[J].Nutrition Research, 2021, 85:47-59.
[55] LIU J F, LIU Y H, CHEN C M, et al.The effect of almonds on inflammation and oxidative stress in Chinese patients with type 2 diabetes mellitus:A randomized crossover controlled feeding trial[J].European Journal of Nutrition, 2013, 52(3):927-935.
[56] SWEAZEA K L, JOHNSTON C S, RICKLEFS K D, et al.Almond supplementation in the absence of dietary advice significantly reduces C-reactive protein in subjects with type 2 diabetes[J].Journal of Functional Foods, 2014, 10:252-259.
[57] KUO P, RAYNER C K, HOROWITZ M.Gastric emptying, diabetes, and aging[J].Clinics in Geriatric Medicine, 2007, 23(4):785-808.
[58] JOSSE A R, KENDALL C W C, AUGUSTIN L S A, et al.Almonds and postprandial glycemia:A dose-response study[J].Metabolism, 2007, 56(3):400-404.
[59] COHEN A E, JOHNSTON C S.Almond ingestion at mealtime reduces postprandial glycemia and chronic ingestion reduces hemoglobin A1c in individuals with well-controlled type 2 diabetes mellitus[J].Metabolism, 2011, 60(9):1312-1317.
[60] COLLIER G, O’DEA K.The effect of coingestion of fat on the glucose, insulin, and gastric inhibitory polypeptide responses to carbohydrate and protein[J].The American Journal of Clinical Nutrition, 1983, 37(6):941-944.
