食品与发酵工业 >

2026 , Vol. 52 >Issue 6: 192 - 201

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.042963

研究报告

天麻保健食品组方规律及主要保健功能研究

  • 贾凡凡 ,
  • 康思锐 ,
  • 张骁睿 ,
  • 张博丰 ,
  • 陈琛
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  • 1(秦巴生物资源与生态环境省部共建国家重点实验室(培育),陕西理工大学 生物科学与工程学院,陕西 汉中,723000)
    2(陕西汉王略阳中药科技有限公司,陕西 略阳,724300)
第一作者:硕士研究生(陈琛教授为通信作者,E-mail:cchen@snut.edu.cn)

收稿日期: 2025-04-09

  修回日期: 2025-08-22

  网络出版日期: 2026-04-10

基金资助

陕西省重点研发项目(2025NC-YBXM-308);陕西省教育厅重点科学研究计划项目(23JY017);陕西理工大学“市校共建”科研专项(SXC-2301);陕西理工大学科研项目(SLGRCQD045);陕西理工大学研究生创新基金项目(SLGYCX2527)

收起

Research on the formation pattern and main health functions of Gastrodia elata Blume health foods

  • JIA Fanfan ,
  • KANG Sirui ,
  • ZHANG Xiaorui ,
  • ZHAGN Bofeng ,
  • CHEN Chen
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  • 1(Qinba State Key Laboratory of Biological Resources and Ecological Environment (Incubation), College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China)
    2(Shaanxi Hanwang Lueyang Traditional Chinese Medicine Technology Co.Ltd., Lueyang 724300, China)

Received date: 2025-04-09

  Revised date: 2025-08-22

  Online published: 2026-04-10

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摘要

该文为明确含天麻保健食品的组方规律及其发挥主要保健功能的作用机制,通过统计国家市场监督管理总局中注册的含天麻保健食品,分析其批文年份、剂型、保健功能以及适宜/禁忌人群等基本信息,随后对其进行中药原料频数统计与关联规则分析,并通过网络药理学及分子对接技术对天麻保健食品发挥的主要保健功能作用机制进行探究。共收集到136种含天麻的保健食品,其中胶囊剂数量最多;涉及11种保健功能,主要为有助于改善睡眠、有助于增强免疫力以及有助于维持血压健康水平;组成原料共涉及96种中药,主要以温、甘为主;并获得天麻有效成分161个、靶点1 037个,主要通过神经活性配体与受体的相互作用、PI3K-AKT、HIF-1等信号通路发挥主要保健作用。通过数据挖掘、网络药理学技术对含天麻保健食品的组方规律、保健功能以及潜在靶点与作用机制进行预测分析,可为天麻保健食品的研发提供参考依据。

关键词： 天麻; 保健食品; 数据挖掘; 网络药理学; 改善睡眠; 增强免疫力; 维持血压健康水平

本文引用格式

贾凡凡 , 康思锐 , 张骁睿 , 张博丰 , 陈琛 . 天麻保健食品组方规律及主要保健功能研究[J]. 食品与发酵工业, 2026 , 52(6) : 192 -201 . DOI: 10.13995/j.cnki.11-1802/ts.042963

Abstract

This study aims to clarify the formulae of health food products containing Gastrodia elata Blume (G.elata) and the mechanism of its main health functions.Through the statistics of health food containing G.elata registered in the State Administration for Market Supervision and Administration, the basic information such as the year of approval, dosage form, health function and suitable/contraindicated groups were analysed, and frequency statistics and association rule analysis were also carried out.The main mechanisms of health functions exerted by G.elata health food products were also investigated through network pharmacology and molecular docking technology.As a result, a total of 136 health food products containing G.elata were collected, of which the largest number was in capsule form;11 health functions were involved, mainly helping to improve sleep, helping to enhance immunity, and helping to maintain a healthy level of blood pressure;a total of 96 traditional Chinese medicines (TCM) were involved in the composition of raw materials, with warmth and sweetness being the main ones;and 161 active ingredients and 1 037 targets of G.elata were obtained, which exerted their main health effects mainly through signaling pathways such as the interactions of neuroactive ligands and receptors, PI3K-AKT, HIF1 and other signaling pathways.Data mining and network pharmacology techniques can predict the formulation mode, health functions and potential action targets and mechanism of action of health food products containing G.elata, and provide a reference basis for the research and development of G.elata-related products.

Key words： Gastrodia elata Blume; health product; data mining; network pharmacology; improving sleep; enhancing immunity; maintaining healthy blood pressure levels

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