综述与专题评论

后生元工艺研究进展及产品开发现状

  • 黄秋幸 ,
  • 蓝素桂 ,
  • 廖秋眉 ,
  • 蒙海妹 ,
  • 邝山 ,
  • 肖桂龙 ,
  • 罗卫飞 ,
  • 梁艳 ,
  • 姜珊
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  • 1(广西爱生生命科技有限公司,广西 南宁,530007)
    2(四川爱生生命科技有限公司,四川 达州,635000)
第一作者:本科,助理工程师(蓝素桂硕士和梁艳中级工程师为共同通信作者,E-mail:1957206053@qq.com;478037020@qq.com)

收稿日期: 2025-11-06

  修回日期: 2026-01-22

  网络出版日期: 2026-09-21

Research progress on postbiotic technology and current status of product development

  • HUANG Qiuxing ,
  • LAN Sugui ,
  • LIAO Qiumei ,
  • MENG Haimei ,
  • KUANG Shan ,
  • XIAO Guilong ,
  • LUO Weifei ,
  • LIANG Yan ,
  • JIANG Shan
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  • 1(Guang Xi AIage Life Science Co.Ltd., Nanning 530007, China)
    2(Si Chuan AIage Life Science Co.Ltd., Dazhou 635000, China)

Received date: 2025-11-06

  Revised date: 2026-01-22

  Online published: 2026-09-21

摘要

后生元是指通过灭活益生菌或其发酵产物获得的生物活性物质,包括代谢产物、细胞成分等。随着益生菌功能机制研究的深化、灭活技术的突破及活性成分分离鉴定技术的发展,益生菌产业逐渐从“活菌时代”迈向“成分时代”,后生元作为一种新型功能性成分,是益生菌产业发展中增长最快的新赛道之一。近年来,后生元因其稳定的生物活性和广泛的应用潜力备受关注,在食品、日化、医药和农业等领域发挥重要作用。该文系统综述了后生元的工艺研究进展及产品开发现状,以期为后生元的生产及其相关产品开发与产业化应用提供参考和实践指导。

本文引用格式

黄秋幸 , 蓝素桂 , 廖秋眉 , 蒙海妹 , 邝山 , 肖桂龙 , 罗卫飞 , 梁艳 , 姜珊 . 后生元工艺研究进展及产品开发现状[J]. 食品与发酵工业, 2026 , 52(17) : 422 -432 . DOI: 10.13995/j.cnki.11-1802/ts.045081

Abstract

Postbiotics are defined as preparations of inanimate microorganisms and/or their cellular components that confer health benefit on the host.These valuable compounds are typically derived from probiotics through inactivation processes or are obtained from fermentation metabolites.As the functional mechanisms of probiotics are further elucidated, alongside breakthroughs in inactivation technologies and advancements in the isolation and characterization of active components, the probiotic industry is progressively transitioning from the "live-cell era" to the "component-driven era." Within this shift, postbiotics have emerged as a novel functional ingredient, establishing themselves as one of the fastest-growing and most promising frontiers in the probiotic sector.In recent years, significant attention has been directed toward postbiotics due to their stable biological activities and extensive application potential, leading to their critical roles across diverse sectors including food, consumer chemicals, pharmaceuticals, and agriculture.This article systematically reviews recent progress in postbiotic production technologies and the current landscape of product development, with the aim of providing valuable references and practical guidance for the industrial-scale manufacturing and application of postbiotics and related products.

参考文献

[1] Salminen S, Collado M C, Endo A, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics[J]. Nature Reviews Gastroenterology & Hepatology, 2021, 18(9):649-667.
[2] Smolinska S, Popescu F D, Zemelka-Wiacek M. A review of the influence of prebiotics, probiotics, synbiotics, and postbiotics on the human gut microbiome and intestinal integrity[J]. Journal of Clinical Medicine, 2025, 14(11):3673.
[3] Zavišić G, Ristić S, Petričević S, et al. Microbial contamination of food: Probiotics and postbiotics as potential biopreservatives[J]. Foods, 2024, 13(16):2487.
[4] 井昭轩, 梁配新, 韩雪梅, 等. 植物乳植杆菌IOB602后生元调节神经内分泌及肠道微生态改善小鼠抑郁样行为[J]. 食品科学, 2025, 46(14):168-178.
Jing Z X, Liang P X, Han X M, et al. Lactiplantibacillus plantarum IOB602 postbiotic ameliorates depression-like behaviors by regulating neuroendocrine factors and gut microbiota in mice[J]. Food Science, 2025, 46(14):168-178.
[5] Scott E, de Paepe K, Van de Wiele T. Postbiotics and their health modulatory biomolecules[J]. Biomolecules, 2022, 12(11):1640.
[6] Ali Noori S M, Behfar A, Saadat A, et al. Antimicrobial and antioxidant properties of natural postbiotics derived from five lactic acid bacteria[J]. Jundishapur Journal of Natural Pharmaceutical Products, 2022, 18(1): e130785.
[7] Aghebati-Maleki L, Hasannezhad P, Abbasi A, et al. Antibacterial, antiviral, antioxidant, and anticancer activities of postbiotics: A review of mechanisms and therapeutic perspectives[J]. Biointerface Research in Applied Chemistry, 2021, 12(2): 2629-2645.
[8] Jalali S, Mojgani N, Haghighat S, et al. Investigation of antimicrobial and antioxidant properties of postbiotics produced by Lactobacillus rhamnosus and Limosilactobacillus reuteri and their potential application in surface decontamination of red meat[J]. LWT, 2024, 209:116758.
[9] Jastrząb R, Graczyk D, Siedlecki P. Molecular and cellular mechanisms influenced by postbiotics[J]. International Journal of Molecular Sciences, 2021, 22(24):13475.
[10] Szydłowska A, Sionek B. Probiotics and postbiotics as the functional food components affecting the immune response[J]. Microorganisms, 2022, 11(1):104.
[11] Yeşilyurt N, Yılmaz B, ğagündüz D, et al. Involvement of probiotics and postbiotics in the immune system modulation[J]. Biologics, 2021, 1(2):89-110.
[12] Jeong W B, Kim Y S, Shin H Y, et al. Macrophage activation of postbiotics fractions prepared from lactic acid bacteria isolated from kimchi[J]. Current Topic in Lactic Acid Bacteria and Probiotics, 2024, 10(1):40-48.
[13] Li H Y, Zhou D D, Gan R Y, et al. Effects and mechanisms of probiotics, prebiotics, synbiotics, and postbiotics on metabolic diseases targeting gut microbiota: A narrative review[J]. Nutrients, 2021, 13(9):3211.
[14] Ayechu-Muruzabal V, Xiao L, Wehkamp T, et al. A fermented milk matrix containing postbiotics supports Th1- and Th17-type immunity in vitro and modulates the influenza-specific vaccination response in vivo in association with altered serum galectin ratios[J]. Vaccines, 2021, 9(3):254.
[15] Xie J Y, Li H, Zhang X A, et al. Akkermansia muciniphila protects mice against an emerging tick-borne viral pathogen[J]. Nature Microbiology, 2023, 8(1):91-106.
[16] Park M, Joung M, Park J H, et al. Role of postbiotics in diet-induced metabolic disorders[J]. Nutrients, 2022, 14(18):3701.
[17] Wu W M, Chen Z F, Han J N, et al. Endocrine, genetic, and microbiome nexus of obesity and potential role of postbiotics: A narrative review[J]. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2023, 28(1):84.
[18] Cani P D, Knauf C. A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion[J]. Cell Metabolism, 2021, 33(6):1073-1075.
[19] Yoon H S, Cho C H, Yun M S, et al. Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice[J]. Nature Microbiology, 2021, 6(5):563-573.
[20] Xie M X, Ye J L, Chen H Q, et al. Effects and mechanisms of probiotics, prebiotics, synbiotics and postbiotics for the prevention and management of type 2 diabetes mellitus[J]. Food Reviews International, 2025, 41(7):2203-2218.
[21] Liu C, Cai T Y, Cheng Y L, et al. Postbiotics prepared using Lactobacillus reuteri ameliorates ethanol-induced liver injury by regulating the FXR/SHP/SREBP-1c axis[J]. Molecular Nutrition & Food Research, 2024, 68(14): e2300927.
[22] Arellano-García L I, Milton-Laskibar I, Martínez J A, et al. Comparative effects of viable Lactobacillus rhamnosus GG and its heat-inactivated paraprobiotic in the prevention of high-fat high-fructose diet-induced non-alcoholic fatty liver disease in rats[J]. BioFactors, 2025, 51: e2116.
[23] Park S J, Sharma A, Lee H J. Postbiotics against obesity: Perception and overview based on pre-clinical and clinical studies[J]. International Journal of Molecular Sciences, 2023, 24(7):6414.
[24] 郑立婷, 汪哲, 陈玉春, 等. 嗜黏蛋白阿克曼菌在非酒精性脂肪性肝病中的作用[J]. 临床肝胆病杂志, 2024, 40(3):594-599.
Zheng L T, Wang Z, Chen Y C, et al. Role of Akkermansia muciniphila in nonalcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2024, 40(3):594-599.
[25] 李异轩, 任晓萌. 后生元的制备和营养作用的相关研究进展[J]. 中国微生态学杂志, 2025, 37(5):617-621.
Li Y X, Ren X M. The preparation and nutritional effects of postbiotics: Research progress[J]. Chinese Journal of Microecology, 2025, 37(5):617-621.
[26] Aran K R, Porel P, Hunjan G, et al. Postbiotics as a therapeutic tool in Alzheimer’s disease: Insights into molecular pathways and neuroprotective effects[J]. Ageing Research Reviews, 2025, 106:102685.
[27] Chudzik A, Orzyłowska A, Rola R, et al. Probiotics, prebiotics and postbiotics on mitigation of depression symptoms: Modulation of the brain-gut-microbiome axis[J]. Biomolecules, 2021, 11(7):1000.
[28] Zdybel K, Śliwka A, Polak-Berecka M, et al. Postbiotics formulation and therapeutic effect in inflammation: A systematic review[J]. Nutrients, 2025, 17(13):2187.
[29] Bashir B, Alam S, Khandale N, et al. Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation[J]. Ageing Research Reviews, 2024, 95:102236.
[30] Abedin M M, Chourasia R, Phukon L C, et al. Lactic acid bacteria in the functional food industry: Biotechnological properties and potential applications[J]. Critical Reviews in Food Science and Nutrition, 2024, 64(29):10730-10748.
[31] 肖桂龙, 罗卫飞, 芦志龙, 等. 一种抗氧化、减脂和抑制肿瘤生长的广西阿克曼氏菌及其产品与应用: CN202310332284.3[P]. 2023-08-22.
Xiao G L, Luo W F, Lu Z L, et al. An antioxidant, fat-reducing and tumor growth-inhibiting Akkermansia guangxiensis and its products and applications: CN202310332284.3 [P]. 2023-08-22.
[32] 罗卫飞,蒙丽丽,柴智慧, 等.一种延长寿命、抗衰老、减脂的罗伊氏乳杆菌及其产品与应用: CN202280067122.5 [P].2024-07-23.
Luo W F, Meng L L, Chai Z H, et al. An Lactobacillus rhamnosus for extending lifespan, anti-aging, and fat reduction, its products and applications: CN118019840B[P]. 2024-07-23.
[33] 谢莹莹, 庞旭, 周海泳, 等. 后生元的作用机制及其在食品领域的应用[J]. 食品科学, 2024, 45(8):354-363.
Xie Y Y, Pang X, Zhou H Y, et al. Action mechanisms of postbiotics and their applications in food field[J]. Food Science, 2024, 45(8):354-363.
[34] Rahman M M, Sazili A Q, Ahmad S A, et al. Inhibitory efficacy, production dynamics, and characterization of postbiotics of lactic acid bacteria[J]. BMC Microbiology, 2025, 25(1):485.
[35] Seara M F M De A. Sustainable production of postbiotics for food applications[D]. Porto: Universidade Catolica Portuguesa, 2023.
[36] Tong Y C, Guo H N, Abbas Z, et al. Optimizing postbiotic production through solid-state fermentation with Bacillus amyloliquefaciens J and Lactiplantibacillus plantarum SN4 enhances antibacterial, antioxidant, and anti-inflammatory activities[J]. Frontiers in Microbiology, 2023, 14:1229952.
[37] Almahbashi A, Gunes Altuntas E. From preparation to bioactivity: A comparative study on preparation methods and characterization of postbiotics[J]. Food Science & Nutrition, 2025, 13(5): e70294.
[38] G R S K, V M. Scaling up postbiotics production: A prospective review of processes and health benefits[J]. Probiotics and Antimicrobial Proteins, 2026, 18(2):2870-2889.
[39] Sun Z, Zhao Z, Fang B, et al. Effect of thermal inactivation on antioxidant, anti-inflammatory activities and chemical profile of postbiotics[J]. Foods, 2023, 12(19):3579.
[40] Zhu Y, Xiao M L, Kang T Y, et al. The role of inactivation methods in shaping postbiotic composition and modulating bioactivity: A review[J]. Foods, 2025, 14(13):2358.
[41] Porfiri L, Burtscher J, Kangethe R T, et al. Irradiated non-replicative lactic acid bacteria preserve metabolic activity while exhibiting diverse immune modulation[J]. Frontiers in Veterinary Science, 2022, 9:859124.
[42] 陆寒池, 于文皓, 于洋, 等. 后生元的生物功能及其应用研究进展[J]. 食品安全质量检测学报, 2025, 16(9):1-11.
Lu H C, Yu W H, Yu Y, et al. Research progress on the biological functions and applications of postbiotics[J]. Journal of Food Safety & Quality, 2025, 16(9):1-11.
[43] 刘翠平, 叶蕾, 吴正钧, 等. 干酪乳杆菌LC2W胞外多糖提取工艺研究[J]. 华北农学报, 2008, 23(B10):118-121.
Liu C P, Ye L, Wu Z J, et al. Optimization of preparation procedures for exopolysaccharides from Lactobacillus casei LC2W[J]. Acta Agriculturae Boreali-Sinica, 2008, 23(B10):118-121.
[44] Sørensen H M, Rochfort K D, Maye S, et al. Exopolysaccharides of lactic acid bacteria: Production, purification and health benefits towards functional food[J]. Nutrients, 2022, 14(14):2938.
[45] Asarat M, Vasiljevic T, Ravikumar M, et al. Extraction and purification of short-chain fatty acids from fermented reconstituted skim milk supplemented with inulin[J]. Food Analytical Methods, 2016, 9(11):3069-3079.
[46] Zheng X, Chen T, Li W L, et al. Rapid purification and quantification of intestinal and fecal short-chain fatty acids by solid-phase extraction using bond elut plexa[J]. Separations, 2024, 11(9):270.
[47] Ou C C, Lu T M, Tsai J J, et al. Antioxidative effect of lactic acid bacteria: Intact cells vs. intracellular extracts[J]. Journal of Food and Drug Analysis, 2010, 17(3): 6.
[48] Kim W, Lee E J, Bae I H, et al. Lactobacillus plantarum-derived extracellular vesicles induce anti-inflammatory M2 macrophage polarization in vitro[J]. Journal of Extracellular Vesicles, 2020, 9(1):1793514.
[49] Gao J, Li Y B, Wan Y, et al. A novel postbiotic from Lactobacillus rhamnosus GG with a beneficial effect on intestinal barrier function[J]. Frontiers in Microbiology, 2019, 10:477.
[50] 闫梦娜, 孙韵琪, 刘晴晴, 等. 发酵粘液乳杆菌IOB802对小鼠骨骼生长的影响[J]. 食品安全质量检测学报, 2024, 15(1):314-320.
Yan M N, Sun Y Q, Liu Q Q, et al. Effects of Limosilactobacillus fermentum IOB802 on bone growth in mice[J]. Journal of Food Safety and Quality, 2024, 15(1):314-320.
[51] Abot A, Brochot A, Pomié N, et al. Pasteurized Akkermansia muciniphila improves glucose metabolism is linked with increased hypothalamic nitric oxide release[J]. Heliyon, 2023, 9(7): e18196.
[52] Fang H, Rodrigues e-Lacerda R, Barra N G, et al. Postbiotic impact on host metabolism and immunity provides therapeutic potential in metabolic disease[J]. Endocrine Reviews, 2025, 46(1):60-79.
[53] Fogacci F, Giovannini M, Di Micoli V, et al. Effect of supplementation of a butyrate-based formula in individuals with liver steatosis and metabolic syndrome: A randomized double-blind placebo-controlled clinical trial[J]. Nutrients, 2024, 16(15):2454.
[54] Zhang T, Zhang W Q, Feng C J, et al. Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model[J]. npj Science of Food, 2022, 6:53.
[55] Abd El-Ghany W A. Paraprobiotics and postbiotics: Contemporary and promising natural antibiotics alternatives and their applications in the poultry field[J]. Open Veterinary Journal, 2020, 10(3):323-330.
[56] Ragavan M L, Hemalatha S. The functional roles of short chain fatty acids as postbiotics in human gut: Future perspectives[J]. Food Science and Biotechnology, 2024, 33(2):275-285.
[57] 肖灵, 唐琳琳, 宋晓妍, 等. 后生元调节肠道微生态及减少脑内β-淀粉样蛋白沉积改善阿尔茨海默病大鼠的认知障碍[J]. 食品科学, 2025, 46(5):182-193.
Xiao L, Tang L L, Song X Y, et al. Postbiotics regulate intestinal microbiota and reduce amyloid β-protein deposition in the brain, thereby ameliorating cognitive impairment in rats with Alzheimer’s disease[J]. Food Science, 2025, 46(5):182-193.
[58] Cui H C, Feng C R, Guo C Q, et al. Development of novel topical anti-acne cream containing postbiotics for mild-to-moderate acne: An observational study to evaluate its efficacy[J]. Indian Journal of Dermatology, 2022, 67(6):667-673.
[59] da Silva Vale A, de Melo Pereira G V, de Oliveira A C, et al. Production, formulation, and application of postbiotics in the treatment of skin conditions[J]. Fermentation, 2023, 9(3):264.
[60] 袁会敏, 刘银辉. 后生元在皮肤健康与美容领域的开发与应用[J]. 中国微生态学杂志, 2023, 35(12):1475-1482.
Yuan H M, Liu Y H. Development and application of postbiotics in skin health and beauty field[J]. Chinese Journal of Microecology, 2023, 35(12):1475-1482.
[61] Lentini G, Nigro F, Colucci Cante R, et al. Functional properties of an oat-based postbiotic aimed at a potential cosmetic formulation[J]. Fermentation, 2022, 8(11):632.
[62] Puebla-Barragan S, Reid G. Probiotics in cosmetic and personal care products: Trends and challenges[J]. Molecules, 2021, 26(5):1249.
[63] 李冠楠, 王海玲, 王小咪, 等. 益生菌和后生元制剂在化妆品和女性私护品中应用的机遇与挑战[J]. 微生物前沿, 2023(1):1-9.
Li G N, Wang H L, Wang X M, et al. Opportunities and challenges of application of the probiotics/postbiotics in cosmetics and female personal care products[J]. Advances in Microbiology, 2023(1):1-9.
[64] Homayouni Rad A, Pourjafar H, Mirzakhani E. A comprehensive review of the application of probiotics and postbiotics in oral health[J]. Frontiers in Cellular and Infection Microbiology, 2023, 13:1120995.
[65] Molina D, Marinas I C, Angamarca E, et al. Postbiotic-based extracts from native probiotic strains: A promising strategy for food preservation and antimicrobial defense[J]. Antibiotics, 2025, 14(3):318.
[66] Isaac-Bamgboye F J, Mgbechidinma C L, Onyeaka H, et al. Exploring the potential of postbiotics for food safety and human health improvement[J]. Journal of Nutrition and Metabolism, 2024, 2024:1868161.
[67] Ramazanidoroh F, Hosseininezhad M, Shahrampour D, et al. Edible packaging as a functional carrier of prebiotics, probiotics, and postbiotics to boost food safety, quality, and shelf life[J]. Probiotics and Antimicrobial Proteins, 2024, 16(4):1327-1347.
[68] Khani N, Shakeri A H, Moosavy M H, et al. Potential application of postbiotics as a natural preservative in cheese[J]. Probiotics and Antimicrobial Proteins, 2026, 18(1):1512-1526.
[69] Morán J, Kilasoniya A. Integration of postbiotics in food products through attenuated probiotics: A case study with lactic acid bacteria in bread[J]. Foods, 2024, 13(13):2042.
[70] Abbasi A, Sabahi S, Bazzaz S, et al. An edible coating utilizing Malva sylvestris seed polysaccharide mucilage and postbiotic from Saccharomyces cerevisiae var. boulardii for the preservation of lamb meat[J]. International Journal of Biological Macromolecules, 2023, 246:125660.
[71] Mosallaie F, Falah F, Yazdi F T, et al. Development of postbiotic supplemented polylactic acid films for improving quality and shelf life of rainbow trout[J]. Scientific Reports, 2025, 15:24305.
[72] 王纪鹏, 虢有婕, 韩毅, 等. pH敏感性材料在智能食品包装中的应用进展[J]. 食品工业科技, 2023, 44(1):48-55.
Wang J P, Guo Y J, Han Y, et al. Application progress of pH-sensitive materials in smart food packaging[J]. Science and Technology of Food Industry, 2023, 44(1):48-55.
[73] Hosseini S A, Abbasi A, Sabahi S, et al. Application of postbiotics produced by lactic acid bacteria in the development of active food packaging[J]. Biointerface Research in Applied Chemistry, 2021, 12(5):6164-6183.
[74] Rosales Cavaglieri L A, Isgro M C, Aminahuel C, et al. Exploring the potential of lactic acid bacteria to produce postbiotics with antimicrobial and antioxidant properties: Focus on the probiotic strain Pediococcus pentosaceus RC007 for industrial-scale production[J]. International Journal of Food Science and Technology, 2025, 60: vvae003.
[75] Thorakkattu P, Khanashyam A C, Shah K, et al. Postbiotics: Current trends in food and pharmaceutical industry[J]. Foods, 2022, 11(19):3094.
[76] 刘红霞,李雪利,吴秀英,等. 后生元研究进展及应用现状[J]. 食品科学, 2024, 45(1): 326-333.
Liu H X, Li X L, Wu X Y, et al. Progress on research and application of postbiotics[J]. Food Science, 2024(1):326-333.
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