Abstract: Constipation is a common gastrointestinal disease, and the incidence is increasing year by year. Clinical studies have found that the intestinal microbiota of patients with constipation is imbalanced. Regulating the intestinal microbiota by giving the host a certain amount of active probiotics has become an important means of treating constipation. In this study, two strains of Lactobacillus paracasei with different constipation relief effects were selected for research. It was once again confirmed that only L. paracasei LPC-F derived from the feces of healthy adults had the effect of relieving constipation by detecting the constipation-related indicators. Furthermore, we analyzed the possible ways of L. paracasei LPC-F to relieve constipation by detecting the constipation-related gastrointestinal regulatory peptides, serum inflammatory factors, the number of colonic Cajal interstitial cells, intestinal microbiota and its metabolite SCFAs and other indicators. The results indicated that L. paracasei LPC-F increased the level of acetic acid by changing the structure of the intestinal microbiota. Acetic acid stimulated the release of 5-HT from enterochromaffin cells, and 5-HT, which released into the intestinal lumen, bound to its receptor to promote the proliferation of interstitial cells of Cajal, thereby ultimately enhancing intestinal peristalsis and alleviating constipation.
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2022, Vol. 48 
