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辣椒素降糖作用及其机制研究进展

  • 张世奇 ,
  • 唐兰兰 ,
  • 孙劲毅 ,
  • 杨娟 ,
  • 惠永海
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  • 1(岭南师范学院 化学化工学院,广东 湛江,524048)
    2(西南大学 食品科学学院,重庆,400700)
博士,讲师 (惠永海副教授为通讯作者,E-mail:hyhai97@126.com)

收稿日期: 2020-02-28

  网络出版日期: 2020-08-04

基金资助

国家自然科学基金项目(31471581);岭南师范学院人才专项(ZL1817)

Research progress on hypoglycemic effect and mechanism of capsaicin

  • ZHANG Shiqi ,
  • TANG Lanlan ,
  • SUN Jinyi ,
  • YANG Juan ,
  • HUI Yonghai
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  • 1(School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, China)
    2(Department of Food Science, Southwest University, Chongqing 400700, China)

Received date: 2020-02-28

  Online published: 2020-08-04

摘要

辣椒作为被广泛消费的蔬菜和香料之一,不仅能赋予食品特殊的风味,而且具有独特的生理功能。大量研究表明,辣椒素作为辣椒中提取的天然活性成分之一,在防治糖尿病及并发症方面具有显著效果。文章从糖代谢调控、改善胰腺功能、介导瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1, TRPV1)离子通道、调控内分泌系统以及调节肠道菌群等5个方面阐述辣椒素的抗糖尿病效果及其作用机制,评估其作为抗糖尿病药或辅助药剂的潜力,以期为后续防治糖尿病的相关研究提供理论依据。

本文引用格式

张世奇 , 唐兰兰 , 孙劲毅 , 杨娟 , 惠永海 . 辣椒素降糖作用及其机制研究进展[J]. 食品与发酵工业, 2020 , 46(13) : 262 -269 . DOI: 10.13995/j.cnki.11-1802/ts.023790

Abstract

As one of the most widely consumed vegetables and spices in the world, chili pepper not only gives food a special flavor, but also has unique physiological functions. A large amount of research evidence indicates that as one of the natural active ingredients extracted from chili pepper, capsaicin has significant effects in preventing and treating diabetes and complications. The anti-diabetic effect of capsaicin and its mechanism of action are described from five aspects: regulation of glucose metabolism, improvement of pancreatic function, mediation of TRPV1 (transient receptor potential vanilloid 1) ion channels, regulation of endocrine system, and intestinal flora. Simultaneously, the paper evaluates the potential of capsaicin as an anti-diabetic drug or adjuvant, intending to provide a theoretical basis for subsequent research on the prevention and treatment of diabetes.

参考文献

[1] GAVIN III J R, ALBERTI K, DAVIDSON M B, et al. Report of the expert committee on the diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 1997, 20(7): 1 183.
[2] CHO N H, SHAW J E, KARURANGA S, et al. IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045[J]. Diabetes Research and Clinical Practice, 2018, 138: 271-281.
[3] BÜYÜKBALCI A, EL S N. Determination of in vitro antidiabetic effects, antioxidant activities and phenol contents of some herbal teas[J]. Plant Foods for Human Nutrition, 2008, 63(1): 27-33.
[4] SRINIVASAN K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts[J]. International Journal of Food Sciences and Nutrition, 2005, 56(6): 399-414.
[5] 张晶, 孙长波, 石磊岭, 等. RP-HPLC法测定辣椒中辣椒素、二氢辣椒素和降二氢辣椒素含量[J]. 药物分析杂志, 2011, 31(2): 244-246.
[6] CHAIYASIT K, KHOVIDHUNKIT W, WITTAYALERTPANYA S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level[J]. Chotmaihet Thangphaet, 2009, 92(1):108-113.
[7] KIM H S, KWON H J, KIM G E, et al. Attenuation of natural killer cell functions by capsaicin through a direct and TRPV1-independent mechanism[J]. Carcinogenesis, 2014, 35(7): 1 652-1 660.
[8] TOLAN I, RAGOOBIRSINGH D, MORRISON E Y S A. The effect of capsaicin on blood glucose, plasma insulin levels and insulin binding in dog models[J]. Phytotherapy Research, 2001, 15(5): 391-394.
[9] OKUMURA T, TSUKUI T, HOSOKAWA M, et al. Effect of caffeine and capsaicin on the blood glucose levels of obese/diabetic KK-Ay mice[J]. Journal of Oleo Science, 2012, 61(9): 515-523.
[10] AKIBA Y, KATO S, KATSUBE K, et al. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet β cells modulates insulin secretion in rats[J]. Biochemical and Biophysical Research Communications, 2004, 321(1): 219-225.
[11] KWON D Y, KIM Y S, RYU S Y, et al. Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats[J]. The Journal of Nutritional Biochemistry, 2013, 24(6): 1 078-1 085.
[12] ZHANG S, YOU Y, LIU J, et al. Hypoglycaemic effect of capsaicinoids via elevation of insulin level and inhibition of glucose absorption in streptozotocin-induced diabetic rats[J]. Journal of Functional Foods, 2018, 51: 94-103.
[13] KANG J H, TSUYOSHI G, LE NGOC H, et al. Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice[J]. Journal of Medicinal Food, 2011, 14(3): 310-315.
[14] LAGISETTY U, MOHAMMED H, RAMAIAH S. Effect of capsaicin on pharmacodynamic and pharmacokinetics of gliclazide in animal models with diabetes[J]. Pharmacognosy Research, 2018, 10(4): 437.
[15] ZHANG S, MA X, ZHANG L, et al. Capsaicin reduces blood glucose by increasing insulin levels and glycogen content better than capsiate in streptozotocin-induced diabetic rats[J]. Journal of Agricultural and Food Chemistry, 2017, 65(11): 2 323-2 330.
[16] AHUJA K D, ROBERTSON I K, GERAGHTY D P, et al. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism[J]. The American Journal of Clinical Nutrition, 2006, 84(1): 63-69.
[17] YUAN L J, QIN Y, WANG L, et al. Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns[J]. Clinical Nutrition, 2016, 35(2): 388-393.
[18] LEJEUNE M P G M, KOVACS E M R, WESTERTERP-PLANTENGA M S. Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects[J]. British Journal of Nutrition, 2003, 90(3): 651-659.
[19] BELZA A,JESSEN A B. Bioactive food stimulants of sympathetic activity: effect on 24 h energy expenditure and fat oxidation[J]. European Journal of Clinical Nutrition, 2005, 59(6): 733-741.
[20] YOSHIOKA M, LIM K, KIKUZATO S, et al. Effects of red-pepper diet on the energy metabolism in men[J]. Journal of Nutritional Science and Vitaminology, 1995, 41(6): 647-656.
[21] DÖMÖTÖR A, SZOLCSÁNYI J, MÓZSIK G. Capsaicin and glucose absorption and utilization in healthy human subjects[J]. European Journal of Pharmacology, 2006, 534(1): 280-283.
[22] 张世奇, 秦春青, 王倩倩, 等. 辣椒素对1型糖尿病大鼠糖代谢影响作用的研究[J]. 营养学报, 2017, 39(1): 76-80.
[23] JITRAPAKDEE S. Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis[J]. The International Journal of Biochemistry & Cell Biology, 2012, 44(1): 33-45.
[24] KAMAGATE A, DONG H H. FoxO1 integrates insulin signaling to VLDL production[J]. Cell Cycle, 2008, 7(20): 3 162-3 170.
[25] SHIMABUKURO M, HIGA M, ZHOU Y-T, et al. Lipoapoptosis in beta-cells of obese prediabeticfa/fa rats role of serine palmitoyltransferase overexpression[J]. Journal of Biological Chemistry, 1998, 273(49): 32 487-32 490.
[26] UNNO M, NATA K, NOGUCHI N, et al. Production and characterization of reg knockout mice: reduced proliferation of pancreatic β-cells in reg knockout mice[J]. Diabetes, 2002, 51(Suppl 3): S478-S483.
[27] ISLAM M S, LOOTS T DU. Experimental rodent models of type 2 diabetes: a review[J]. Methods and Findings in Experimental and Clinical Pharmacology, 2009, 31(4): 249-261.
[28] 张世奇. 辣椒素对I型糖尿病大鼠糖代谢的影响及其降糖机制的研究[D]. 重庆: 西南大学, 2017.
[29] OKAMOTO H, TAKASAWA S. Recent advances in the okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (REG)-reg receptor system in β-cells[J]. Diabetes, 2002, 51(Suppl 3): S462-S473.
[30] BASSO L, ABOUSHOUSHA R, FAN C Y, et al. TRPV1 promotes opioid analgesia during inflammation[J]. Science Signaling, 2019, 12(575):1-14.
[31] DERBENEV A V, ZSOMBOK A. Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity[J]. Seminars in Immunopathology, 2016, 38(3): 397-406.
[32] 王沛坚. 激活TRPV1上调UCP2防治糖脂代谢紊乱致动脉粥样病变的机制研究[D]. 重庆: 第三军医大学, 2013.
[33] ZHONG B, MA S, WANG D H. TRPV1 mediates glucose-induced insulin secretion through releasing neuropeptides[J]. In Vivo, 2019, 33(5): 1 431-1 437.
[34] KARAM J B, CAI W, MOHAMED R, et al. TRPV1 neurons regulate β-cell function in a sex-dependent manner[J]. Molecular Metabolism, 2018, 18: 60-67.
[35] SUN J, PU Y, WANG P, et al. TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction[J]. Cardiovascular Diabetology, 2013, 12(1): 69.
[36] DIAZ-GARCIA C M, MORALES-LÁZARO S L, SÁNCHEZ-SOTO C, et al. Role for the TRPV1 channel in insulin secretion from pancreatic beta cells[J]. The Journal of Membrane Biology, 2014, 247(6): 479-491.
[37] AHRÉN B. Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice [J].American Journal of Physiology-Regulatory, Integrative and Comparative Physiology,2004,286(2):R269-R272.
[38] WANG P, YAN Z, ZHONG J, et al. Transient receptor potential vanilloid 1 activation enhances gut glucagon-like peptide-1 secretion and improves glucose homeostasis[J]. Diabetes, 2012, 61(8): 2 155-2 165.
[39] GAUTHIER B R, BRUN T, SARRET E J, et al. Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets[J]. Journal of Biological Chemistry, 2004, 279(30): 31 121-31 130.
[40] WATANABE T, KAWADA T, KUROSAWA M, et al. Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats[J]. American Journal of Physiology-Endocrinology and Metabolism, 1988, 255(1): E23-E27.
[41] UCHIDA K, DEZAKI K, YONESHIRO T, et al. Involvement of thermosensitive TRP channels in energy metabolism[J]. The Journal of Physiological Sciences, 2017, 67(5): 549-560.
[42] FESTA ANDREAS, D’AGOSTINO RALPH, HOWARD GEORGE, et al. Chronic subclinical inflammation as part of the insulin resistance syndrome[J]. Circulation, 2000, 102(1): 42-47.
[43] MEHTA N N, MCGILLICUDDY F C, ANDERSON P D, et al. Experimental endotoxemia induces adipose inflammation and insulin resistance in humans[J]. Diabetes, 2010, 59(1): 172-181.
[44] 刘小翠, 胡郁刚, 陈伟忠. 阿卡波糖对糖尿病患者肠道菌群的影响[J]. 黑龙江医学, 2017, 41(6): 541-542.
[45] BABOOTA R K, MURTAZA N, JAGTAP S, et al. Capsaicin-induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice[J]. The Journal of Nutritional Biochemistry, 2014, 25(9): 893-902.
[46] EVERARD A, BELZER C, GEURTS L, et al. Cross-talk between akkermansia muciniphila and intestinal epithelium controls diet-induced obesity[J]. Proceedings of the National Academy of Sciences, 2013, 110(22): 9 066-9 071.
[47] 康超. 辣椒素通过调节肠道菌群发挥改善高脂膳食诱导小鼠肥胖体征//2017中国营养医学发展论坛暨全军营养医学大会论文汇编[C].呼和浩特: 中国营养学会, 2017: 28.
[48] 沈伟. 辣椒素对高脂饮食诱导肥胖小鼠肠道菌群的影响研究[D]. 重庆: 第三军医大学, 2017.
[49] 程亚娇, 王倩倩, 陆红佳, 等. 辣椒素对糖尿病大鼠肠道健康的影响[J]. 食品科学, 2015, 36(9): 154-159.
[50] CARLSSON P O, SANDLER S, JANSSON L. Influence of the neurotoxin capsaicin on rat pancreatic islets in culture, and on the pancreatic islet blood flow of rats[J]. European Journal of Pharmacology, 1996, 312(1): 75-81.
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