食品与发酵工业 >

2020 , Vol. 46 >Issue 19: 264 - 270

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.024455

综述与专题评论

缺铁对肠道免疫功能的影响及新型补铁剂的研究进展

  • 管玲娟 ,
  • 曹丛丛 ,
  • 屠飘涵 ,
  • 成向荣
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  • (江南大学 食品学院,江苏 无锡,214122)
第一作者:硕士研究生(成向荣副教授为通讯作者,E-mail:cheng-xiangrong@hotmail.com)

收稿日期: 2020-05-19

  修回日期: 2020-06-09

  网络出版日期: 2020-11-02

基金资助

国家自然科学基金项目(31700301)

收起

Research progress of the effect of iron deficiency on intestinal immune function and new iron supplements

  • GUAN Lingjuan ,
  • CAO Congcong ,
  • TU Piaohan ,
  • CHEN Xiangrong
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  • (School of Food Science and Technology, Jiangnan University, Wuxi 214122, China)

Received date: 2020-05-19

  Revised date: 2020-06-09

  Online published: 2020-11-02

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摘要

铁是人体必需微量元素,广泛参与机体氧气运输、电子传递等基本生物学过程。铁摄入需要有严密的调节机制以确保机体铁稳态,而维持机体铁稳态主要通过肠道铁吸收的精细调控实现。铁广泛参与特异性免疫系统如免疫活性细胞及其细胞因子,以及非特异性免疫系统如吞噬细胞补体系统等功能调控。肠道微生物与机体铁稳态调控密切相关且影响机体免疫系统功能。铁缺乏会导致肠道菌群平衡和多样性发生显著变化,对肠道免疫具有潜在的影响。本文综述了机体铁稳态、缺铁对肠道菌群、免疫的影响及新型补铁剂的开发,提出铁可能作为一类“抑生元”,影响肠道菌群平衡,新型补铁剂的开发应关注宿主、肠道菌群的整体影响,为新型补铁剂的开发及缺铁相关疾病的预防和干预提供了新的思路。

关键词： 铁稳态; 免疫; 肠道菌群; 补铁剂

本文引用格式

管玲娟 , 曹丛丛 , 屠飘涵 , 成向荣 . 缺铁对肠道免疫功能的影响及新型补铁剂的研究进展[J]. 食品与发酵工业, 2020 , 46(19) : 264 -270 . DOI: 10.13995/j.cnki.11-1802/ts.024455

Abstract

Iron is an essential trace element for the human body and is widely involved in basic biological processes such as oxygen transport and electron transport. Iron intake requires a strict adjustment mechanism to ensure the body's iron homeostasis, and maintaining the body's iron homeostasis is mainly achieved through fine regulation of intestinal iron absorption. Iron is widely involved in the functional regulation of specific immune systems such as immunocompetent cells and their cytokines and non-specific immune systems such as the phagocyte complement system. Intestinal microbes are closely related to the regulation of body iron homeostasis and affect the body's immune system function. Iron deficiency can cause significant changes in the balance and diversity of intestinal flora which could potentially affect intestinal immunity. This article reviews the effects of iron homeostasis, iron deficiency on intestinal flora and immunity, and the development of new iron supplements. It is proposed that iron may be used as a class of “de-biotics” to affect the balance of intestinal flora. New iron supplements development should focus on the overall impact of the host and intestinal flora, and provide new ideas for the development of new iron supplements so as to prevent and intervene with iron deficiency-related diseases.

Key words： iron homeostasis; immunity; gut microbiota; iron supplement

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