黑曲霉是食品和生物工程行业中应用广泛的微生物。黑曲霉菌丝球在液态培养中有提高传质,容易分离菌体,提高生物量,提高产物含量等诸多优点,在柠檬酸生产、海藻收获、污水处理、酶生产等方面都有成功应用。黑曲霉菌丝球在培养过程中会受到多种因素的影响,例如p H、孢子浓度、营养成分、培养条件、黑曲霉的生长状态等。该文综述了黑曲霉形成菌丝球的机理和形成技术,总结了它在多个方面的应用。

Aspergillus niger is an important microbial cell factory in food and biotechnology industries. It formed fungal pellets in submerge fermentation and thus improved mass transfer rate,cell harvest efficiency,cell biomass and bioproducts,and et al. Aspergillus niger cell pellets were successfully applied in citric acid production,algae harvest,wastewater treatment,and enzyme production. The bioprocess of Aspergillus niger cell pellets formation was affected by many factors,such as p H,spores concentration,nutrients,culture condition,and physiological status of Aspergillus niger hyphae. In this paper,the mechanism of fungal pellets formation was summarized,and the bioprocess technologies for Aspergillus niger cell pellets formation and its major applications were reviewed.