食品与发酵工业 >

2022 , Vol. 48 >Issue 19: 320 - 327

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.031506

综述与专题评论

功能红曲液态发酵的研究进展

  • 尚学平 ,
  • 许世锦 ,
  • 陈罗华周 ,
  • 陈玲娟
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  • (广东天益生物科技有限公司,广东 湛江,524300)
第一作者：大专,助理工程师(许世锦工程师为通信作者,E-mail:xu_shijin@163.com)

收稿日期: 2022-03-10

  修回日期: 2022-04-24

  网络出版日期: 2022-11-01

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Research progress of submerged fermentation of functional Monascus

  • SHANG Xueping ,
  • XU Shijin ,
  • CHEN Luohuazhou ,
  • CHEN Lingjuan
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  • (Guangdong Tianyi Biotechnology Co.Ltd., Zhanjiang 524300, China)

Received date: 2022-03-10

  Revised date: 2022-04-24

  Online published: 2022-11-01

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摘要

红曲菌液态发酵可以产生众多的次级代谢产物,尤其以功能红曲Monacolin K及其类似物为代表的活性物质,为当今研究的重点。该文概述了Monacolin K的生物活性与生物合成,以及功能红曲液态发酵的控制策略,重点分析了在红曲菌液态发酵中,通过菌种筛选、培养基构建、补料工艺构建、发酵条件构建、代谢途径控制方法构建等方面来提高Monacolin K产量的途径。同时,对当前功能红曲行业的现状、以不含甘油的原料为碳源的液态发酵如何突破低产Monacolin K的瓶颈和相关政策法规的完善进行了探讨。

关键词： 红曲菌; Monacolin K; 生物合成; 液态发酵; 控制策略

本文引用格式

尚学平 , 许世锦 , 陈罗华周 , 陈玲娟 . 功能红曲液态发酵的研究进展[J]. 食品与发酵工业, 2022 , 48(19) : 320 -327 . DOI: 10.13995/j.cnki.11-1802/ts.031506

Abstract

Monascus submerged fermentation can produce many secondary metabolites, especially the active substances represented by functional Monacolin K and its analogues, which are the focus of current research. The research studied the bioactivity and biosynthesis of Monacolin K and the control strategy of submerged fermentation of functional Monascus, focused on the methods to improve the yield of Monacolin K including strain screening, culture medium optimization, feeding process, fermentation conditions, metabolic pathway control method construction ,etc. At the same time, current situation of functional Monascus industry is prospected, how to break through the bottleneck of low-yield Monacolin K with glycerol-free raw materials as carbon sources is discussed, as well as the existing problems of relevant policies and regulations in the industry.

Key words： Monascus; Monacolin K; biosynthesis; submerged fermentation; control strategy

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