综述与专题评论

食源性黄酮通过肠道菌群调节Ⅱ型糖尿病的作用机制研究进展

  • 曹维 ,
  • 金杜欣 ,
  • 刘瑞 ,
  • 吴满刚 ,
  • 葛庆丰 ,
  • 于海
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  • 1(扬州大学 食品科学与工程学院,江苏 扬州,225127)
    2(扬州大学 广陵学院,江苏 扬州,225000)
第一作者:硕士研究生(金杜欣讲师为通信作者,E-mail:jinduxin@yzu.edu.cn)

收稿日期: 2023-02-14

  修回日期: 2023-03-17

  网络出版日期: 2024-02-27

基金资助

扬州大学大学生科技创新基金资助(X20220889);江苏省高等学校自然科学研究面上项目 (21KJB350021)

Research progress on the mechanism of food-derived flavonoids regulating type Ⅱ diabetes mellitus via gut microbiota

  • CAO Wei ,
  • JIN Duxin ,
  • LIU Rui ,
  • WU Mangang ,
  • GE Qingfeng ,
  • YU Hai
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  • 1(School of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China)
    2(Guangling college of Yangzhou university, Yangzhou 225000, China)

Received date: 2023-02-14

  Revised date: 2023-03-17

  Online published: 2024-02-27

摘要

黄酮类化合物是一类广泛存在于水果和蔬菜中的植物次生代谢产物。大量研究证明,黄酮类化合物具有调节Ⅱ型糖尿病的作用,而肠道菌群在其中扮演着重要的角色。一方面肠道菌群可提高黄酮化合物在体内的生物利用度;另一方面黄酮类可以调节肠道菌群组成和丰度,促进有益代谢产物的产生,改善Ⅱ型糖尿病的发展。因此,肠道菌群可能是黄酮类化合物改善Ⅱ型糖尿病的重要途径。该文对黄酮类化合物对肠道菌群的调节作用,肠道菌群对黄酮类化合物的吸收、代谢、转化以及黄酮类化合物通过肠道菌群调节Ⅱ型糖尿病的作用机制的研究进展进行综述,有望提出新的Ⅱ型糖尿病治疗思路。

本文引用格式

曹维 , 金杜欣 , 刘瑞 , 吴满刚 , 葛庆丰 , 于海 . 食源性黄酮通过肠道菌群调节Ⅱ型糖尿病的作用机制研究进展[J]. 食品与发酵工业, 2024 , 50(2) : 372 -378 . DOI: 10.13995/j.cnki.11-1802/ts.035141

Abstract

Flavonoids are a class of secondary metabolites that are widely distributed in fruits and vegetables. Accumulating evidence suggests the alleviative effect of flavonoids in type Ⅱ diabetes mellitus, while gut microbiota plays a significant role in it. On one hand, gut microbiota can improve the bioavailability of flavonoids; on the other hand, flavonoids can improve the development of type Ⅱ diabetes by regulating the composition and abundance of gut microbiota and promoting the production of beneficial metabolites. Thus, intestinal flora may be an important approach for flavonoids to improve type Ⅱ diabetes. In this review, we provide an update on recent advances in the modulatory effect of flavonoids on gut microbiota, the role of gut microbiota on the absorption, metabolism and transformation of flavonoids, and the mechanism of flavonoids in ameliorating type Ⅱ diabetes via gut microbiota, which could provide new ideas for the treatment of type Ⅱ diabetes.

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