[1] SALEEM M H, ALI S, HUSSAIN S, et al.Flax (Linum usitatissimum L.):A potential candidate for phytoremediation? biological and economical points of view[J].Plants, 2020, 9(4):496.
[2] SHIM Y Y, GUI B, ARNISON P G, et al.Flaxseed (Linum usitatissimum L.) bioactive compounds and peptide nomenclature:A review[J].Trends in Food Science & Technology, 2014, 38(1):5-20.
[3] PARIKH M, NETTICADAN T, PIERCE G N.Flaxseed:Its bioactive components and their cardiovascular benefits[J].American Journal of Physiology-Heart and Circulatory Physiology, 2018, 314(2):H146-H159.
[4] PATEL A K, CHAUHAN A S, KUMAR P, et al.Emerging prospects of microbial production of omega fatty acids:Recent updates[J].Bioresource Technology, 2022, 360:127534.
[5] GONÇALVES N B, BANNITZ R F, SILVA B R, et al.α-Linolenic acid prevents hepatic steatosis and improves glucose tolerance in mice fed a high-fat diet[J].Clinics, 2018, 73:e150.
[6] BUCKNER A L, BUCKNER C A, MONTAUT S, et al.Treatment with flaxseed oil induces apoptosis in cultured malignant cells[J].Heliyon, 2019, 5(8):e02251.
[7] MAKI K C, EREN F, CASSENS M E, et al.ω-6 polyunsaturated fatty acids and cardiometabolic health:Current evidence, controversies, and research gaps[J].Advances in Nutrition, 2018, 9(6):688-700.
[8] RUTTING S, PAPANICOLAOU M, XENAKI D, et al.Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD[J].Respiratory Research, 2018, 19(1):1-12.
[9] WU J H Y, MARKLUND M, IMAMURA F, et al.Omega-6 fatty acid biomarkers and incident type 2 diabetes:Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies[J].The Lancet Diabetes & Endocrinology, 2017, 5(12):965-974.
[10] SINGH K K, MRIDULA D, REHAL J, et al.Flaxseed:A potential source of food, feed and fiber[J].Critical Reviews in Food Science and Nutrition, 2011, 51(3):210-222.
[11] 张志颖, 张琳璐, 白英, 等.提取方法对亚麻籽胶提取率及理化性质的影响[J].食品与发酵工业, 2022, 48(18):219-226.
ZHANG Z Y, ZHANG L L, BAI Y, et al.Effect of extraction methods on extraction rate and physical and chemical properties of flaxseed gum[J].Food and Fermentation Industries, 2022, 48(18):219-226.
[12] YANG C, HU C, ZHANG H, et al.Optimation for preparation of oligosaccharides from flaxseed gum and evaluation of antioxidant and antitumor activities in vitro[J].International Journal of Biological Macromolecules, 2020, 153:1107-1116.
[13] BONGARTZ U, HOCHMANN U, GRUBE B, et al.Flaxseed mucilage (IQP-LU-104) reduces body weight in overweight and moderately obese individuals in a 12-week, three-arm, double-blind, randomized, and placebo-controlled clinical study[J].Obesity Facts, 2022, 15(3):395-404.
[14] 禹晓, 黄沙沙, 聂成镇, 等.亚麻籽胶结构及功能应用研究进展[J].食品研究与开发, 2020, 41(1):212-217.
YU X, HUANG S S, NIE C Z, et al.Research progress of the structure and functional application of flaxseed gum[J].Food Research and Development, 2020, 41(1):212-217.
[15] PULIGUNDLA P, LIM S.A review of extraction techniques and food applications of flaxseed mucilage[J].Foods, 2022, 11(12):1677.
[16] BASIRI S, HAIDARY N, SHEKARFOROUSH S S, et al.Flaxseed mucilage:A natural stabilizer in stirred yogurt[J].Carbohydrate Polymers, 2018, 187:59-65.
[17] DE PAIVA P H E N, CORREA L G, PAULO A F S, et al.Film production with flaxseed mucilage and polyvinyl alcohol mixtures and evaluation of their properties[J].Journal of Food Science and Technology, 2021, 58(8):3030-3038.
[18] 王维义, 许帅强, 何宏燕, 等.亚麻籽的营养成分及功能研究进展[J].中国油脂, 2020, 45(4):83-85.
WANG W Y, XU S Q, HE H Y, et al.Progress in nutrients and function of flaxseed[J].China Oils and Fats, 2020, 45(4):83-85.
[19] AQEEL T, GURUMALLU S C, BHASKAR A, et al.Protective role of flaxseed lignan secoisolariciresinol diglucoside against lead-acetate-induced oxidative-stress-mediated nephrotoxicity in rats[J].Phytomedicine Plus, 2021, 1(3):100038.
[20] HAJIBABAIE F, ABEDPOOR N, SAFAVI K, et al.Natural remedies medicine derived from flaxseed (secoisolariciresinol diglucoside, lignans, and α-linolenic acid) improve network targeting efficiency of diabetic heart conditions based on computational chemistry techniques and pharmacophore modeling[J].Journal of Food Biochemistry, 2022, 46(12):e14480.
[21] GUO Y J, YANG X L, TSE T J, et al.Hypocholesterolemic efficacy of secoisolariciresinol diglucoside and its polymer in rat[J].Journal of Natural Products, 2021, 84(11):2845-2850.
[22] ROM S, ZULUAGA-RAMIREZ V, REICHENBACH N L, et al.Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent:Implications for neuroinflammation[J].Journal of Neuroinflammation, 2018, 15(1):25.
[23] TANNOUS S, HAYKAL T, DHAINI J, et al.The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells[J].Biomedicine & Pharmacotherapy, 2020, 132:110884.
[24] CHANG V C, COTTERCHIO M, BOUCHER B A, et al.Effect of dietary flaxseed intake on circulating sex hormone levels among postmenopausal women:A randomized controlled intervention trial[J].Nutrition and Cancer, 2019, 71(3):385-398.
[25] DI Y Y, DE SILVA F, KROL E S, et al.Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3[J].Nutrition and Cancer, 2018, 70(2):306-315.
[26] TAN N H, ZHOU J.Plant cyclopeptides[J].Chemical Reviews, 2006, 106(3):840-895.
[27] KAUFMANN H P, TOBSCHIRBEL A.Über ein oligopeptid aus leinsamen[J].Chemische Berichte, 1959, 92(11):2805-2809.
[28] 邹仙果. 亚麻籽环肽组成、氧化结构变化及其体外抗肿瘤抗炎活性研究[D].南昌:南昌大学, 2019.
ZOU X G.Study on composition, oxidation structure and anti-tumor and anti-inflammatory activity of flaxseed cyclic peptide in vitro antitumor and anti-inflammatory activities of linusorbs in flaxseed(Linum usitatissimum L.)[D].Nanchang:Nanchang University, 2019.
[29] LANG T, FRANK O, LANG R, et al.Activation spectra of human bitter taste receptors stimulated with cyclolinopeptides corresponding to fresh and aged linseed oil[J].Journal of Agricultural and Food Chemistry, 2022, 70(14):4382-4390.
[30] SHIM Y Y, SONG Z L, JADHAV P D, et al.Orbitides from flaxseed (Linum usitatissimum L.):A comprehensive review[J].Trends in Food Science & Technology, 2019, 93:197-211.
[31] SHIM Y Y, YOUNG L W, ARNISON P G, et al.Proposed systematic nomenclature for orbitides[J].Journal of Natural Products, 2015, 78(4):645-652.
[32] MORITA H, SHISHIDO A, MATSUMOTO T, et al.A new immunosuppressive cyclic nonapeptide, cyclolinopeptide B from Linum usitatissimum L.[J].Bioorganic & Medicinal Chemistry Letters, 1997, 7(10):1269-1272.
[33] MORITA H, SHISHIDO A, MATSUMOTO T, et al.Cyclolinopeptides B - E, new cyclic peptides from Linum usitatissimum[J].Tetrahedron, 1999, 55(4):967-976.
[34] MATSUMOTO T, SHISHIDO A, MORITA H, et al.Cyclolinopeptides F-I, cyclic peptides from linseed[J].Phytochemistry, 2001, 57(2):251-260.
[35] STEFANOWICZ P.Detection and sequencing of new cyclic peptides from linseed by electrospray ionization mass spectrometry[J].Acta Biochimica Polonica, 2001, 48(4):1125-1129.
[36] BRÜHL L, MATTHÄUS B, FEHLING E, et al.Identification of bitter off-taste compounds in the stored cold pressed linseed oil[J].Journal of Agricultural and Food Chemistry, 2007, 55(19):7864-7868.
[37] JADHAV P D, OKINYO-OWITI D P, AHIAHONU P W K, et al.Detection, isolation and characterisation of cyclolinopeptides J and K in ageing flax[J].Food Chemistry, 2013, 138(2-3):1757-1763.
[38] OKINYO-OWITI D P, BURNETT P G G, REANEY M J T.Simulated moving bed purification of flaxseed oil orbitides:Unprecedented separation of cyclolinopeptides C and E[J].Journal of Chromatography B, 2014, 965:231-237.
[39] BURNETT P G G, JADHAV P D, OKINYO-OWITI D P, et al.Glycine-containing flaxseed orbitides[J].Journal of Natural Products, 2015, 78(4):681-688.
[40] LIU X, CAI Z, LEE W J, et al. A practical and fast isolation of 12 cyclolinopeptides (linusorbs) from flaxseed oil via preparative HPLC with phenyl-hexyl column[J]. Food Chemistry, 2021, 351:129318.
[41] 李红艳, 邓泽元, 邹仙果.一种通过生成环肽晶体制备高纯度环肽单体的方法:CN109438562B[P].2021-09-28.
LI H Y, DENG Z Y, ZOU X G.A method for preparing high-purity cyclolinopeptide monomers by generating cyclolinopeptide crystals:CN109438562B[P].2021-09-28.
[42] BREWSTER A I, BOVEY F A.Conformation of cyclolinopeptide a observed by nuclear magnetic resonance spectroscopy[J].Proceedings of the National Academy of Sciences of the United States of America, 1971, 68(6):1199-1202.
[43] TANCREDI T, BENEDETTI E, GRIMALDI M, et al.Ion binding of cyclolinopeptide A:An NMR and CD conformational study[J].Biopolymers, 1991, 31(6):761-767.
[44] STEFANOWICZ P.Electrospray mass spectrometry and tandem mass spectrometry of the natural mixture of cyclic peptides from linseed[J].European Journal of Mass Spectrometry, 2004, 10(5):665-671.
[45] FOJNICA A, LEIS H J, MURKOVIC M.Identification and characterization of the stability of hydrophobic cyclolinopeptides from flaxseed oil[J].Frontiers in Nutrition, 2022, 9:903611.
[46] ZIMECKI M, KACZMAREK K.Effects of modifications on the immunosuppressive properties of cyclolinopeptide A and its analogs in animal experimental models[J].Molecules, 2021, 26(9):2538.
[47] KATARZYŃSKA J, ARTYM J, KOCHANOWSKA I, et al.4-Methylpseudoproline analogues of cyclolinopeptide A:Synthesis, structural analysis and evaluation of their suppressive effects in selected immunological assays[J].Peptides, 2020, 132:170365.
[48] KANEDA T, NAKAJIMA Y, KOSHIKAWA S, et al.Cyclolinopeptide F, a cyclic peptide from flaxseed inhibited RANKL-induced osteoclastogenesis via downergulation of RANK expression[J].Journal of Natural Medicines, 2019, 73(3):504-512.
[49] ZOU X G, HU J N, LI J, et al.iCellular uptake of[1-9-NαC]-linusorb B2 and[1-9-NαC]-linusorb B3 isolated from flaxseed, and their antitumor activities in human gastric SGC-7901 cells[J].Journal of Functional Foods, 2018,48:692-703.
[50] TANIGUCHI Y, YAMAMOTO N, HAYASHI K, et al.Anti-tumor effects of cyclolinopeptide on giant-cell tumor of the bone[J].Anticancer Research, 2019, 39(11):6145-6153.
[51] SUNG N Y, JEONG D, SHIM Y Y, et al.The anti-cancer effect of linusorb B3 from flaxseed oil through the promotion of apoptosis, inhibition of actin polymerization, and suppression of src activity in glioblastoma cells[J].Molecules, 2020, 25(24):5881.
[52] ALMOUSA A A, MEURENS F, KROL E S, et al.Linoorbitides and enterolactone mitigate inflammation-induced oxidative stress and loss of intestinal epithelial barrier integrity[J].International Immunopharmacology, 2018, 64:42-51.
[53] BELL A, MCSTEEN P M, CEBRAT M, et al.Antimalarial activity of cyclolinopeptide A and its analogues[J].Acta Poloniae Pharmaceutica, 2000, 57:134-136.
[54] LIU Y J, LIU Y, LI P P, et al.Antibacterial properties of cyclolinopeptides from flaxseed oil and their application on beef[J].Food Chemistry, 2022, 385:132715.
[55] 刘尊, 汪勇, MARTIN J T REANEY, 等.亚麻籽环肽混合物抑制霉菌生长繁殖活性[J].食品与发酵工业, 2018, 44(3):30-34.
LIU Z, WANG Y, REANEY M J T, et al.Antifungal activity of flaxseed cyclolinopeptides mixtures[J].Food and Fermentation Industries, 2018, 44(3):30-34.
