研究采用喷雾干燥法制备了壳聚糖-叶酸微胶囊,并对该微胶囊的粒度、形态、生物可及性、溶出特性进行了探究。结果表明,制备的壳聚糖-叶酸微胶囊颗粒大小均匀,中位径为17.78 μm,形状不规则,表面为多孔状结构。在经过胃肠道4 h消化后,其生物可及性相较于未包埋叶酸(73.95%),提高至85.04%,且高于市面上4种叶酸补充剂。溶出特性的研究结果表明,壳聚糖的溶胀过程使叶酸被缓慢释放,通过模型拟合发现Baker-Lonsdale模型与该溶出过程的拟合效果最好。该研究为叶酸的高价值化利用提供理论依据和数据支持。
彭雅萱
,
丁振江
,
李旭燕
,
杨宗玲
,
刘金洋
,
王俊
,
陆伟
,
冯煦洸
,
夏凯
,
周志桥
. 壳聚糖-叶酸微胶囊的制备及其特性评价[J]. 食品与发酵工业, 2024
, 50(5)
: 149
-155
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DOI: 10.13995/j.cnki.11-1802/ts.034395
This study prepared the chitosan-folic acid microcapsules by spray drying method, and then evaluated the particle size, morphology, bioaccessibility, and dissolution characteristics of the microcapsules.Results showed that the prepared chitosan-folic acid microcapsules were of uniform particle size with a median diameter of 17.78 μm, irregular shape, and a porous surface.After 4 h digestion in the gastrointestinal tract, bioaccessibility was effectively increased to 85.04% compared to 73.95% for unembedded folic acid and was higher than that of four market folic acid supplements.Studies on the dissolution characteristics showed that the microcapsules dissolved slowly in water and the Baker-Lonsdale model was the best fit for this dissolution process by model fitting.This study provides a theoretical basis and data support for the high utilization value of folic acid.
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