食品与发酵工业 >

2024 , Vol. 50 >Issue 11: 327 - 335

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.036727

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单增李斯特菌毒力因子及调控机制研究进展

  • 李钊 ,
  • 刘阳泰 ,
  • 李卓思 ,
  • 秦晓杰 ,
  • 王翔 ,
  • 董庆利
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  • (上海理工大学 健康科学与工程学院,上海,200093)
第一作者:博士研究生(董庆利教授为通信作者, E-mail:qdong@usst.edu.cn)

收稿日期: 2023-07-10

  修回日期: 2023-08-01

  网络出版日期: 2024-07-12

基金资助

上海市农委2021年度上海市科技兴农技术创新项目(X2021-02-08-00-12-F00782);上海市农业领军人才项目(2022)

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Research progress of virulence factors and regulatory mechanisms of Listeria monocytogenes

  • LI Zhao ,
  • LIU Yangtai ,
  • LI Zhuosi ,
  • QIN Xiaojie ,
  • WANG Xiang ,
  • DONG Qingli
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  • (School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)

Received date: 2023-07-10

  Revised date: 2023-08-01

  Online published: 2024-07-12

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摘要

单增李斯特菌(Listeria monocytogenes)是一种革兰氏阳性食源性致病菌,能在低温、高温、高渗透压等多种不利条件下生长存活。在宿主体内,单增李斯特菌首先寄生于胃肠道,随后穿过肠道屏障,再通过血液传播到靶器官引发系列疾病,整个过程与单增李斯特菌独特的毒力因子及调控机制密切相关。该文首先回顾整理了单增李斯特菌在感染期间关键毒力因子的主要作用及目前新进展,介绍了毒力调控因子(PrfA)和转录调控因子(σB),着重讨论了调控因子在宿主外环境和内环境的相互作用,最后对目前新的毒力调控因子进行归纳总结,为全面理解单增李斯特菌的感染机制和进一步开展精准防控提供一定参考。

关键词： 单增李斯特菌; 感染; 毒力因子; 调控因子

本文引用格式

李钊 , 刘阳泰 , 李卓思 , 秦晓杰 , 王翔 , 董庆利 . 单增李斯特菌毒力因子及调控机制研究进展[J]. 食品与发酵工业, 2024 , 50(11) : 327 -335 . DOI: 10.13995/j.cnki.11-1802/ts.036727

Abstract

Listeria monocytogenes, a gram-positive foodborne pathogen, demonstrates the ability to survive and thrive under adverse conditions, including low temperatures, high temperatures, and high osmotic pressure.Within the host organism, L.monocytogenes initially parasitizes the gastrointestinal tract, subsequently traverses the intestinal barrier, and disseminates through the bloodstream to target organs, giving rise to a series of pathologies.This entire process is closely associated with the unique virulence factors and regulatory mechanisms of L.monocytogenes.This article begins with a thorough review and organization of the pivotal roles played by key virulence factors during L.monocytogenes infection, as well as the latest discoveries in this field.Subsequently, it introduces the virulence regulatory factor (PrfA) and the transcriptional regulatory factor (σB), with a specific focus on discussing the interplay of these regulatory factors within both the extracellular and intracellular environments of the host.Finally, a summarization and synthesis of the current novel virulence regulatory factors are provided, offering essential insights to comprehensively understand infection mechanisms of L.monocytogenes and laying the groundwork for further precise prevention and control measures.

Key words： Listeria monocytogenes; infection; virulence factors; regulatory factors

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