[1] KAMAKURA M. Royalactin induces queen differentiation in honeybees[J]. Nature, 2011, 473(7348):478-483.
[2] KUREK-GÓRECKA A, GÓRECKI M, RZEPECKA-STOJKO A, et al. Bee products in dermatology and skin care[J]. Molecules, 2020, 25(3):556.
[3] KOSEDAG M, GULABOGLU M. Pollen and bee bread expressed highest anti-inflammatory activities among bee products in chronic inflammation: An experimental study with cotton pellet granuloma in rats[J]. Inflammopharmacology, 2023, 31(4):1967-1975.
[4] SCHUH C M A P, AGUAYO S, ZAVALA G, et al. Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity[J]. Journal of Experimental Biology, 2019, 222(Pt 20): jeb208702.
[5] PARK M J, KIM B Y, PARK H G, et al. Major royal jelly protein 2 acts as an antimicrobial agent and antioxidant in royal jelly[J]. Journal of Asia-Pacific Entomology, 2019, 22(3):684-689.
[6] LIMA W G, BRITO J C M, DA CRUZ NIZER W S. Bee products as a source of promising therapeutic and chemoprophylaxis strategies against COVID-19 (SARS-CoV-2)[J]. Phytotherapy Research, 2021, 35(2):743-750.
[7] ASMA S T, BOBIŞ O, BONTA V, et al. General nutritional profile of bee products and their potential antiviral properties against mammalian viruses[J]. Nutrients, 2022, 14(17):3579.
[8] KUNUGI H, MOHAMMED ALI A. Royal jelly and its components promote healthy aging and longevity: From animal models to humans[J]. International Journal of Molecular Sciences, 2019, 20(19):4662.
[9] SAAD AL SHEHRI Z, ALANAZI A D, ALNOMASY S F. Anti-cancer effects of queen bee acid (10-hydroxy-2-decenoic acid) and its cellular mechanisms against human hepatoma cells[J]. Molecules, 2023, 28(4):1972.
[10] ABU-SERIE M M, HABASHY N H. Suppressing crucial oncogenes of leukemia initiator cells by major royal jelly protein 2 for mediating apoptosis in myeloid and lymphoid leukemia cells[J]. Food & Function, 2022, 13(17):8951-8966.
[11] BOTEZAN S, BACI G M, BAGAMERI L, et al. Current status of the bioactive properties of royal jelly: A comprehensive review with a focus on its anticancer, anti-inflammatory, and antioxidant effects[J]. Molecules, 2023, 28(3):1510.
[12] HOSSEN M S, NAHAR T, GAN S H, et al. Bioinformatics and therapeutic insights on proteins in royal jelly[J]. Current Proteomics, 2019, 16(2):84-101.
[13] 海关统计数据在线查询平台.[EB/OL].[2023-10-17].http://stats.customs.gov.cn.
[14] 刘一冰, 吴德群, 蔺哲广, 等. 蜂王浆生物学功能研究进展[J]. 畜牧兽医学报, 2021, 52(6):1498-1510.
LIU Y B, WU D Q, LIN Z G, et al. Review on biological function of royal jelly[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(6):1498-1510.
[15] MAGHSOUDLOU A, MAHOONAK A S, MOHEBODINI H, et al. Royal jelly: Chemistry, storage and bioactivities[J]. Journal of Apicultural Science, 2019, 63(1):17-40.
[16] CHEN C, CHEN S Y. Changes in protein components and storage stability of Royal Jelly under various conditions[J]. Food Chemistry, 1995, 54(2):195-200.
[17] HU F L, BÍLIKOVÁ K, CASABIANCA H, et al. Standard methods for Apis mellifera royal jelly research[J]. Journal of Apicultural Research, 2019, 58(2):1-68.
[18] LI J K, FENG M, ZHANG L, et al. Proteomics analysis of major royal jelly protein changes under different storage conditions[J]. Journal of Proteome Research, 2008, 7(8):3339-3353.
[19] LI J K, WANG T, PENG W J. Comparative analysis of the effects of different storage conditions on major royal jelly proteins[J]. Journal of Apicultural Research, 2007, 46(2):73-80.
[20] KAMAKURA M, SUENOBU N, FUKUSHIMA M. Fifty-seven-kDa protein in royal jelly enhances proliferation of primary cultured rat hepatocytes and increases albumin production in the absence of serum[J]. Biochemical and Biophysical Research Communications, 2001, 282(4):865-874.
[21] KAMAKURA M, FUKUDA T, FUKUSHIMA M, et al. Storage-dependent degradation of 57-kDa protein in royal jelly: A possible marker for freshness[J]. Bioscience, Biotechnology, and Biochemistry, 2001, 65(2):277-284.
[22] 王露露, 董蕊, 范超, 等. 蜂王浆在贮藏过程中5-羟甲基糠醛、10-羟基-2-癸烯酸及精氨酸双糖苷含量的变化[J]. 食品科学, 2016, 37(2):271-275.
WANG L L, DONG R, FAN C, et al. Changes in the contents of 5-HMF, 10-HDA and AFG in royal jelly during storage[J]. Food Science, 2016, 37(2):271-275.
[23] 魏月, 陈芳, 薛晓锋, 等. 蜂王浆贮存过程中糠醛类物质含量的变化[J]. 中国食品学报, 2016, 16(10):222-227.
WEI Y, CHEN F, XUE X F, et al. The change of furfu ral compounds contents of royal jelly during storage[J]. Journal of Chinese Institute of Food Science and Technology, 2016, 16(10):222-227.
[24] CIULU M, FLORIS I, NURCHI V M, et al. A possible freshness marker for royal jelly: Formation of 5-hydroxymethyl-2-furaldehyde as a function of storage temperature and time[J]. Journal of Agricultural and Food Chemistry, 2015, 63(16):4190-4195.
[25] WYTRYCHOWSKI M, PASSÉ J O, CASABIANCA H, et al. Assessment of royal jelly freshness by HILIC LC-MS determination of furosine[J]. Industrial Crops and Products, 2014, 62:313-317.
[26] MARCONI E, CABONI M F, MESSIA M C, et al. Furosine: A suitable marker for assessing the freshness of royal jelly[J]. Journal of Agricultural and Food Chemistry, 2002, 50(10):2825-2829.
[27] 杨焱, 胡九菊, 李林霖, 等. 蜂王浆中超氧化物歧化酶的活性测定与应用[J]. 食品研究与开发, 2022, 43(1):180-185.
YANG Y, HU J J, LI L L, et al. Determination of superoxide dismutase activity and its application in royal jelly[J]. Food Research and Development, 2022, 43(1):180-185.
[28] 吴粹文, 张复兴. 贮存温度和时间对蜂王浆中葡萄糖氧化酶(GOD)活性影响的研究[J]. 中国养蜂, 1990, 41(5):4-6.
WU C W, ZHANG F X. Effects of storage temperature and time on the activity of glucose oxidase (GOD) in royal jelly[J]. Apiculture of China, 1990, 41(5):4-6.
[29] WU L M, WEI Y, DU B, et al. Freshness determination of royal jelly by analyzing decomposition products of adenosine triphosphate[J]. LWT-Food Science and Technology, 2015, 63(1):504-510.
[30] BOSELLI E, CABONI M F, SABATINI A G, et al. Determination and changes of free amino acidsin royal jelly during storage[J]. Apidologie, 2003, 34(2):129-137.
[31] SHEN L R, WANG Y R, ZHAI L, et al. Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody[J]. Journal of Zhejiang University. Science. B, 2015, 16(2):155-166.
[32] LIN N, CHEN S, ZHANG H, et al. Quantification of major royal jelly protein 1 in fresh royal jelly by ultraperformance liquid chromatography-tandem mass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2018, 66(5): 1270-1278.
[33] HU H, WEI Q, SUN Z, et al. Development of a freshness assay for royal jelly based on the temperature- and time-dependent changes of antimicrobial effectiveness and proteome dynamics of royal jelly proteins[J]. J Agric Food Chemistry, 2021, 69(36): 10731-1740.
[34] 陈勇, 江唯健, 王加俊, 等. 超高效液相色谱-串联质谱法定量检测蜂王浆主蛋白1~3[J]. 浙江大学学报(农业与生命科学版), 2022, 48(6):776-786.
CHEN Y, JIANG W J, WANG J J, et al. Quantitative detection of major royal jelly proteins 1-3 by ultra-high performance liquid chromatography-tandem mass spectrometry[J]. Journal of Zhejiang University (Agriculture and Life Sciences), 2022, 48(6):776-786.
[35] 吴黎明, 周群, 赵静, 等. FTIR光谱法整体评价蜂王浆新鲜度的研究[J]. 光谱学与光谱分析, 2009, 29(12):3236-3240.
WU L M, ZHOU Q, ZHAO J, et al. Research on overall assessment of royal jelly freshness by FTIR spectroscopy[J]. Spectroscopy and Spectral Analysis, 2009, 29(12):3236-3240.
[36] 吴亚君, 刘鸣畅, 赵方圆, 等. 采用毛细管凝胶电泳技术检测蜂王浆新鲜度[J]. 食品与发酵工业, 2013, 39(4):161-166.
WU Y J, LIU M C, ZHAO F Y, et al. The detection of royal jelly freshness by capillary gel electrophoresis[J]. Food and Fermentation Industries, 2013, 39(4):161-166.
[37] 吴黎明, 田文礼, 薛晓锋, 等. 高效液相色谱法测定蜂王浆中羟甲基糠醛含量[J]. 食品科学, 2008, 29(3):412-414.
WU L M, TIAN W L, XUE X F, et al. Determination of hydroxymethylfurfural contents in royal jelly by high performance liquid chromatography[J]. Food Science, 2008, 29(3):412-414.
[38] 周骁, 薛晓锋, 吴黎明, 等. 反相离子对色谱法测定蜂王浆中糠氨酸的含量[J]. 食品科学, 2008, 29(5):370-372.
ZHOU X, XUE X F, WU L M, et al. Determination of furosine in royal jelly by ion-pair reversed phase liquid chromatography[J]. Food Science, 2008, 29(5):370-372.
[39] CIULU M, FARRE R, FLORIS I, et al. Determination of 5-hydroxymethyl-2-furaldehyde in royal jelly by a rapid reversed phase HPLC method[J]. Analytical Methods, 2013, 5(19):5010-5013.
[40] QIAO J T, WANG X Y, LIU L Q, et al. Nonenzymatic browning and protein aggregation in royal jelly during room-temperature storage[J]. Journal of Agricultural and Food Chemistry, 2018, 66(8):1881-1888.
[41] WU L M, ZHOU J H, XUE X F, et al. Fast determination of 26 amino acids and their content changes in royal jelly during storage using ultra-performance liquid chromatography[J]. Journal of Food Composition and Analysis, 2009, 22(3):242-249.
[42] 张映, 姜玉锁, 牛建英. 蜂王浆中超氧化物歧化酶活力测定[J]. 山西农业大学学报, 1996, 16(3):267-268; 324-325.
ZHANG Y, JIANG Y S, NIU J Y. Activity test on sod in fresh royal jelly[J]. Journal of Shanxi Agricultural University, 1996, 16(3):267-268; 324-325.
[43] ZHENG H Q, WEI W T, WU L M, et al. Fast determination of royal jelly freshness by a chromogenic reaction[J]. Journal of Food Science, 2012, 77(6): S247-S252.
[44] 易倩, 俞彦波, 罗雪雅, 等. 蜂王浆色泽与新鲜度关联研究[J]. 食品工业科技, 2011, 32(11):171-173.
YI Q, YU Y B, LUO X Y, et al. Study on the association of color and freshness of royal jelly[J]. Science and Technology of Food Industry, 2011, 32(11):171-173.
[45] TIAN W L, LI M, GUO H Y, et al. Architecture of the native major royal jelly protein 1 oligomer[J]. Nature Communications, 2018, 9(1):3373.
[46] 吴黎明. 蜂王浆新鲜度指标和评价方法研究[D]. 杭州: 浙江大学, 2008: 110-125.
WU L M. Study on the freshness index and evaluation method of royal jelly[D]. Hangzhou: Zhejiang University, 2008: 110-125.
[47] 郭城, 吴卫成, 谌迪, 等. 基于ATR-FTIR结合CARS算法测定蜂王浆中水溶性蛋白质和总糖含量[J]. 中国食品学报, 2021, 21(11):183-190.
GUO C, WU W C, CHEN D, et al. Determination of water-soluble protein and total sugar in royal jelly based on attenuated total reflection mid-infrared spectroscopy and CARS algorithm[J]. Journal of Chinese Institute of Food Science and Technology, 2021, 21(11):183-190.
[48] SUNDS A V, RAUH V M, SØRENSEN J, et al. Maillard reaction progress in UHT milk during storage at different temperature levels and cycles[J]. International Dairy Journal, 2018, 77:56-64.
[49] SHAKOOR A, ZHANG C P, XIE J C, et al. Maillard reaction chemistry in formation of critical intermediates and flavour compounds and their antioxidant properties[J]. Food Chemistry, 2022, 393:133416.
[50] ERBERSDOBLER H F, SOMOZA V. Forty years of furosine-forty years of using Maillard reaction products as indicators of the nutritional quality of foods[J]. Molecular Nutrition & Food Research, 2007, 51(4):423-430.
[51] 刘娟, 高铁俊, 董捷, 等. 蜂王浆室温储存过程中的褐变产物[J]. 食品科学, 2012, 33(6):238-241.
LIU J, GAO T J, DONG J, et al. Browning products of royal jelly during storage at room temperature[J]. Food Science, 2012, 33(6):238-241.
[52] GÖKMEN V, SERPEN A, MORALES F J. Determination of furosine in thermally processed foods by hydrophilic interaction liquid chromatography[J]. Journal of AOAC International, 2009, 92(5):1460-1463.
[53] AALAEI K, RAYNER M, SJÖHOLM I. Chemical methods and techniques to monitor early Maillard reaction in milk products; A review[J]. Critical Reviews in Food Science and Nutrition, 2019, 59(12):1829-1839.
[54] ALTUNAY N. Experimental design of magnetic ionic liquid ultrasound-assisted dispersive liquid-liquid microextraction for the determination of 5-HMF in honey samples[J]. Journal of Food Composition and Analysis, 2022, 114:104817.
[55] 朱秀清, 雷文华, 黄雨洋, 等. 5-羟甲基糠醛在食品中的变化及其安全性研究进展[J]. 食品安全质量检测学报, 2022, 13(15):4983-4991.
ZHU X Q, LEI W H, HUANG Y Y, et al. Research progress in changes of 5-hydroxymethylfurfural in food and its safety[J]. Journal of Food Safety & Quality, 2022, 13(15):4983-4991.
[56] LEE C H, CHEN K T, LIN J A, et al. Recent advances in processing technology to reduce 5-hydroxymethylfurfural in foods[J]. Trends in Food Science & Technology, 2019, 93:271-280.
[57] SABATER C, MONTILLA A, OVEJERO A, et al. Furosine and HMF determination in prebiotic-supplemented infant formula from Spanish market[J]. Journal of Food Composition and Analysis, 2018, 66:65-73.
[58] BESIR A, YAZICI F, MORTAS M, et al. A novel spectrophotometric method based on Seliwanoff test to determine 5-(hydroxymethyl) furfural (HMF) in honey: Development, in house validation and application[J]. LWT, 2021, 139:110602.
[59] HONG H, REGENSTEIN J M, LUO Y K. The importance of ATP-related compounds for the freshness and flavor of post-mortem fish and shellfish muscle: A review[J]. Critical Reviews in Food Science and Nutrition, 2017, 57(9):1787-1798.
[60] CAMACHO C, CORREIA T, TEIXEIRA B, et al. Nucleotides and free amino acids in sea urchin Paracentrotus lividus gonads: Contributions for freshness and overall taste[J]. Food Chemistry, 2023, 404:134505.
[61] XU N, ZENG X M, LI L Y, et al. Effects of post-mortem aging process on characteristic water-soluble taste-active precursors in yellow-feathered broilers[J]. Food Science and Human Wellness, 2023, 12(1):242-253.
[62] COLLAZO N, CARPENA M, NUÑEZ-ESTEVEZ B, et al. Health promoting properties of bee royal jelly: Food of the Queens[J]. Nutrients, 2021, 13(2):543.
[63] GIAMPIERI F, QUILES J L, CIANCIOSI D, et al. Bee products: An emblematic example of underutilized sources of bioactive compounds[J]. Journal of Agricultural and Food Chemistry, 2022, 70(23):6833-6848.
[64] BAUER J A, ZÁMOCKÁ M, MAJTÁN J, et al. Glucose oxidase, an enzyme “ferrari”: Its structure, function, production and properties in the light of various industrial and biotechnological applications[J]. Biomolecules, 2022, 12(3):472.
[65] KHATAMI S H, VAKILI O, AHMADI N, et al. Glucose oxidase: Applications, sources, and recombinant production[J]. Biotechnology and Applied Biochemistry, 2022, 69(3):939-950.
[66] SAGONA S, COPPOLA F, GIANNACCINI G, et al. Impact of different storage temperature on the enzymatic activity of Apis mellifera royal jelly[J]. Foods, 2022, 11(20):3165.
[67] KETTLE A J, ASHBY L V, WINTERBOURN C C, et al. Superoxide: The enigmatic chemical chameleon in neutrophil biology[J]. Immunological Reviews, 2023, 314(1):181-196.
[68] ASADI N, KHERADMAND A, GHOLAMI M, et al. Effect of royal jelly on testicular antioxidant enzymes activity, MDA level and spermatogenesis in rat experimental Varicocele model[J]. Tissue and Cell, 2019, 57:70-77.
[69] 袁耀东, 何薇莉, 陈黎红, 等. 鲜王浆中超氧化物歧化酶的初步研究[J]. 中国养蜂, 1993, 44(5):3-5.
YUAN Y D, HE W L, CHEN L H, et al. Preliminary study on SOD(superoxide dismutase)in fresh royal jelly[J]. Apiculture of China, 1993, 44(5):3-5.
[70] LEE Y J. Knockout mouse models for peroxiredoxins[J]. Antioxidants, 2020, 9(2):182.
[71] SINGH R R, REINDL K M. Glutathione S-transferases in cancer[J]. Antioxidants, 2021, 10(5):701.
[72] PEARSON P B, BURGIN C J. The pantothenic acid content of royal jelly[J]. Experimental Biology and Medicine, 1941, 48(2):415-417.
[73] 周才琼, 罗雪雅. 蜂王浆新鲜度指标筛选及新鲜度的评判[J]. 食品与发酵工业, 2010, 36(3):129-132; 140.
ZHOU C Q, LUO X Y. Study on freshness index of royal jelly[J]. Food and Fermentation Industries, 2010, 36(3):129-132; 140.
[74] ISIDOROV V A, BAKIER S, GRZECH I. Gas chromatographic-mass spectrometric investigation of volatile and extractable compounds of crude royal jelly[J]. Journal of Chromatography B, 2012, 885:109-116.
[75] CHEN L L, NING F J, ZHAO L, et al. Quality assessment of royal jelly based on physicochemical properties and flavor profiles using HS-SPME-GC/MS combined with electronic nose and electronic tongue analyses[J]. Food Chemistry, 2023, 403:134392.
[76] CHEN D, LU W J, YE Q, et al. HS-GC-IMS and ATR-FT-MIR analysis reveal the differences in volatile compounds, proteins, and polyphenols of royal jelly[J]. Advances in Materials Science and Engineering, 2022, 2022:3223558.
[77] BÍLIKOVÁ K, SIMÚTH J. New criterion for evaluation of honey: Quantification of royal jelly protein apalbumin 1 in honey by ELISA[J]. Journal of Agricultural and Food Chemistry, 2010, 58(15):8776-8781.
[78] CHÁVEZ-SERVÍN J L, CASTELLOTE A I, LÓPEZ-SABATER M C. Evolution of potential and free furfural compounds in milk-based infant formula during storage[J]. Food Research International, 2006, 39(5):536-543.
[79] 郑火青, 胡福良, 李英华. 蜂王浆新鲜度指标的研究进展[J]. 中国养蜂, 2005, 56(11):30-31.
ZHENG H Q, HU F L, LI Y H. The recent advances in quality index of freshness of royal jelly[J]. Apiculture of China, 2005, 56(11):30-31.