In this study, the contents of Monacolin K, red yeast rice (RYR) pigment, crude polysaccharide, amino acid, polyphenol, and γ-aminobutyric acid were analyzed in four kinds of RYR products (common red yeast rice, functional red yeast rice, fruit RYR, and RYR hyphae).The contents of triglyceride (TG), total cholesterol (T-CHO), and superoxide dismutase (SOD) in the serum of mice were analyzed.Results showed that the content of functional components in different RYR products had obvious differences.In the animal experiment, compared with the model group, all four kinds of samples had the effect of regulating blood lipid, and such effect was enhanced with the increase of dose.In terms of antioxidant function, the four samples did not significantly increase the activity of superoxide dismutase in serum of experimental animals.
[1] 殷梦梅, 叶晖, 张学智.红曲单药及复方制剂治疗高脂血症的研究进展[J].医学综述, 2017, 23(2):344-347.
YIN M M, YE H, ZHANG X Z.Research progress of Monascus purpureus single drug and compound preparation in the treatment of hyperlipidemia[J].Medical Recapitulate, 2017, 23(2):344-347.
[2] 陈春艳. 红曲中功能成分的分离与功能评价[D].武汉:华中农业大学, 2004.
CHEN C Y.Isolation and functional evaluation of functional components in Monascus[D].Wuhan:Huazhong Agricultural University, 2004.
[3] WANG C R, ZAYAS J F.Water retention and solubility of soy proteins and corn germ proteins in a model system[J].Journal of Food Science, 1991, 56(2):455-458.
[4] 刘海荣, 沈益荣, 舒满夫.小麦面筋蛋白结构、改性及应用现状[J].粮食与饲料工业, 2021(4):5-9.
LIU H R, SHEN Y R, SHU M F.Research status on the structure, modification and application of wheat gluten protein[J].Cereal & Feed Industry, 2021(4):5-9.
[5] 张文菱子, 张泽生, 刘亚萍, 等.山楂、甾醇酯及功能红曲复配物的降血脂活性[J].食品工业科技, 2019, 40(20):316-324.
ZHANG W, ZHANG Z S, LIU Y P, et al.Hypolipidemic activity of hawthorn, sterol ester and functional red yeast rice compound[J].Science and Technology of Food Industry, 2019, 40(20):316-324.
[6] WU J, WARREN F J.The impact of the soluble protein fraction and kernel hardness on wheat flour starch digestibility[J].Food Chemistry, 2023, 406:135047.
[7] PATAKOVA P.Monascus secondary metabolites:Production and biological activity[J].Journal of Industrial Microbiology & Biotechnology, 2013, 40(2):169-181.
[8] RAHAYU Y Y, YOSHIZAKI Y, YAMAGUCHI K, et al.Key volatile compounds in red koji-shochu, a Monascus-fermented product, and their formation steps during fermentation[J].Food Chemistry, 2017, 224:398-406.
[9] 林瑾, 周康熙.红曲色素组分分析与功效评估研究进展[J].莆田学院学报, 2023, 30(5):11-18.
LIN J, ZHOU K X.Research progress in component analysis and efficacy evaluation of Monascus pigments[J].Journal of Putian University, 2023, 30(5):11-18.
[10] 郑平, 覃先武, 张彦, 等.高产开环型monacolin K红曲霉菌株的筛选及其在红曲酒酿造中的应用[J].中国酿造, 2023, 42(3):129-134.
ZHENG P, QIN X W, ZHANG Y, et al.Screening of Monascus spp.strain with high-yield open-loop monacolin K and its application in Hongqujiu brewing[J].China Brewing, 2023, 42(3):129-134.
[11] 胡文效, 魏彦锋, 蒋锡龙, 等.高产Monacolin K红曲霉菌种的诱变选育及液态发酵工艺优化[J].食品工业科技, 2013, 34(24):296-301.
HU W X, WEI Y F, JIANG X L, et al.Mutagenic breeding of the high-yield Monacolin k strains of Monascus sp.and process optimization its submerged fermentation[J].Science and Technology of Food Industry, 2013, 34(24):296-301.
[12] ROBINS DAMON H, SEEWALD MEGAN E, CLEMENT BEVERLY A.Development of a rapid detection method for citrinin and monacolin K[J].Abstracts of Papers of the American Chemical Society, 2014, 247.
[13] 唐光甫, 满海乔, 赵杰宏, 等.紫色红曲霉Mrr2基因的过表达对桔霉素积累的影响[J].安徽农业科学, 2023, 51(20):1-5.
TANG G F, MAN H Q, ZHAO J H, et al.Effect of overexpression of Mrr2 gene in Monascus purpureus on citrinin accumulation[J].Journal of Anhui Agricultural Sciences, 2023, 51(20):1-5.
[14] TAKAHASHI R, CHYSIRICHOTE T, ASAMI K, et al.Effect of oxygen mass transfer between the gas and liquid phases on the production of Monascus red pigments by Monascus ruber[J].Journal of Chemical Engineering of Japan, 2013, 46(8):546-549.
[15] BODAKOWSKA-BOCZNIEWICZ J, GARNCAREK Z.Naringinase biosynthesis by Aspergillus niger on an optimized medium containing red grapefruit albedo[J].Molecules, 2022, 27(24):8763.
[16] 洪炳财. 蚕蛹蛋白水解液中游离氨基酸测定方法初探[J].食品工程, 2013(1):11-14.
HONG B C.Primary study on determination method of free amino acids in the Pupa protein hydrolyzate[J].Food Engineering, 2013(1):11-14.
[17] TORRES A M, MAU-LASTOVICKA T, REZAAIYAN R.Total phenolics and high-performance liquid chromatography of phenolic acids of avocado[J].Journal of Agricultural and Food Chemistry, 1987, 35(6):921-925.
[18] 吕道俊, 郭秋平, 欧慧瑜, 等.水溶性番茄浓缩物及复配红曲粉降血脂功效研究[J].现代食品, 2023, 29(21):102-106.
LYU D J, GUO Q P, OU H Y, et al.Study on the assistant hypolipidemic function of water soluble tomato concentrate and compound red yeast powder[J].Modern Food, 2023, 29(21):102-106.
[19] HE T, DONG T.Research on the application of red music in the construction of curriculum civics based on the knowledge dissemination model[J].Applied Mathematics and Nonlinear Sciences, 2024, 9(1):20230762.
[20] 刘科. 功能红曲的发酵生产、品质评价及功能活性成分表征[D].福州:福州大学, 2021.
LIU K.Fermentation production, quality evaluation and characterization of functional active components of functional Monascus[D].Fuzhou:Fuzhou University, 2021.
[21] QIN X L, XIE B, ZONG X L, et al.Selective production, relationship and controversy between Monascus pigments and citrinin[J].Food Bioscience, 2023, 56:103233.
[22] CHEN G, ZHAO W Q, ZHAO L, et al.Regulation of the pigment production by changing cell morphology and gene expression of Monascus ruber in high-sugar synergistic high-salt stress fermentation[J].Journal of Applied Microbiology, 2023, 134(10):lxad207.
[23] CAMPOY S, RUMBERO A, MARTÍN J F, et al.Characterization of an hyperpigmenting mutant of Monascus purpureus IB1:Identification of two novel pigment chemical structures[J].Applied Microbiology and Biotechnology, 2006, 70(4):488-496.
[24] 黄丹丹, 周海媚, 李谣, 等.苦荞红曲保健酒的抗氧化活性[J].中国酿造, 2014, 33(6):99-102.
HUANG D D, ZHOU H M, LI Y, et al.Antioxidant activity of red kojic buckwheat health wine[J].China Brewing, 2014, 33(6):99-102.
[25] KOVALEV S, GOLOVACH A, KOVALEV V, et al.Study and determination of fructan-type polysaccharide content in Erigeron annuus L[J].Current Issues in Pharmacy and Medical Sciences, 2022, 35(2):95-98.
