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监督式机器学习在食品中霉菌毒素检测的应用研究进展

  • 张书鸣 ,
  • 王欣 ,
  • 郑玲春 ,
  • 白亚敏 ,
  • 聂旭元 ,
  • 王锴 ,
  • 许桐 ,
  • FRANCISCO PÉREZ NEVADO ,
  • 王强
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  • 1(重庆第二师范学院 生物与化学工程学院,重庆,400067)
    2(重庆第二师范学院 油脂资源利用与创新重庆市工程研究中心,重庆,400067)
    3(重庆市食品药品检验检测研究院,重庆,401121)
    4(埃斯特雷马杜拉大学,巴达霍斯,06001,西班牙)
第一作者: 硕士,讲师(王强教授为通信作者,E-mail:52320980@qq.com)

收稿日期: 2025-01-15

  修回日期: 2025-03-12

  网络出版日期: 2025-08-01

基金资助

重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0362)重庆市教委科技项目(KJQN202101616)

Advances in supervised machine learning for mycotoxin detection in foods

  • ZHANG Shuming ,
  • WANG Xin ,
  • ZHENG Lingchun ,
  • BAI Yamin ,
  • NIE Xuyuan ,
  • WANG Kai ,
  • XU Tong ,
  • FRANCISCO PÉREZ NEVADO ,
  • WANG Qiang
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  • 1(School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China)
    2(Engineering Research Center of Lipid Resources Utilization and Innovation, Chongqing University of Education, Chongqing Education Commission of China, Chongqing 400067, China)
    3(Chongqing Institute for Food and Drug Control, Chongqing 401121, China)
    4(Universidad de Extremadura, Badajoz 06001, Spain)

Received date: 2025-01-15

  Revised date: 2025-03-12

  Online published: 2025-08-01

摘要

霉菌毒素是霉菌生长过程中产生的有毒次生代谢产物,广泛存在于各类食品中,直接影响食品的质量和人体的健康。为了保障食品安全和人体健康,必须采取有效措施来防止霉菌毒素在食品中的产生和积累。检测霉菌毒素的传统方法存在检测效率较低、灵敏度较差、适用性低等缺点,机器学习作为一种辅助手段,在提升检测准确性和简化实验操作等方面具有促进作用。其中,监督式机器学习因其强大的数据处理能力、精准的预测和分类能力、挖掘潜在食品安全问题的能力以及与其他技术的结合应用能力,已被广泛应用到食品安全的检测中,为食品安全检测提供了有力的支持,有助于保障消费者的健康和权益。该文围绕监督学习在食品中霉菌毒素检测的应用进展,介绍了监督学习的工作流程和常用算法,根据不同算法类型阐述了监督学习在检测食品中霉菌毒素的应用,并对监督学习在食品安全检测领域的发展趋势进行了展望。

本文引用格式

张书鸣 , 王欣 , 郑玲春 , 白亚敏 , 聂旭元 , 王锴 , 许桐 , FRANCISCO PÉREZ NEVADO , 王强 . 监督式机器学习在食品中霉菌毒素检测的应用研究进展[J]. 食品与发酵工业, 2025 , 51(14) : 422 -432 . DOI: 10.13995/j.cnki.11-1802/ts.042148

Abstract

Mycotoxins are toxic secondary metabolites produced during the growth of molds and are widely present in various foods, directly affecting the quality of food and human health.To ensure food safety and human health, effective measures must be taken to prevent the production and accumulation of mycotoxins in food.Traditional methods for detecting mycotoxins have several drawbacks, such as low detection efficiency, poor sensitivity, and limited applicability.Machine learning, as an auxiliary tool, plays a promoting role in improving detection accuracy and simplifying experimental operations.Among these, supervised machine learning, with its powerful data processing capabilities, precise prediction and classification abilities, potential to uncover food safety issues, and the capacity to integrate with other technologies, has been widely applied in food safety detection, providing strong support for ensuring consumer health and rights.This article focuses on the application progress of supervised learning in the detection of mycotoxins in food, introduces the workflow and commonly used algorithms of supervised learning, discusses the application of supervised learning in detecting mycotoxins in food according to different algorithm types, and looks forward to the development trends of supervised learning in the field of food safety detection.

参考文献

[1] KING T, COLE M, FARBER J M, et al. Food safety for food security: Relationship between global megatrends and developments in food safety[J]. Trends in Food Science & Technology, 2017, 68:160-175.
[2] KUMAR P, MAHATO D K, KAMLE M, et al. Aflatoxins: A global concern for food safety, human health and their management[J]. Frontiers in Microbiology, 2017, 7:2170.
[3] 缪伊雯, 白菲, 童华荣. 茶叶中霉菌毒素危害与质量控制研究进展[J]. 食品科学, 2023, 44(17):352-362.
MIAO Y W, BAI F, TONG H R. Research progress on the hazards and control of mycotoxins in tea[J]. Food Science, 2023, 44(17):352-362.
[4] XU H W, WANG L Z, SUN J D, et al. Microbial detoxification of mycotoxins in food and feed[J]. Critical Reviews in Food Science and Nutrition, 2022, 62(18):4951-4969.
[5] KOŚCIELECKA K, KUĆ A, KUBIK-MACHURA D, et al. Endocrine effect of some mycotoxins on humans: A clinical review of the ways to mitigate the action of mycotoxins[J]. Toxins, 2023, 15(9):515.
[6] ZAIN M E. Impact of mycotoxins on humans and animals[J]. Journal of Saudi Chemical Society, 2011, 15(2):129-144.
[7] PAVLENKO R, BERZINA Z, REINHOLDS I, et al. An occurrence study of mycotoxins in plant-based beverages using liquid chromatography-mass spectrometry[J]. Toxins, 2024, 16(1):53.
[8] TSAGKARIS A S, PRUSOVA N, DZUMAN Z, et al. Regulated and non-regulated mycotoxin detection in cereal matrices using an ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC-HRMS) method[J]. Toxins, 2021, 13(11):783.
[9] LIANG Y F, ZHOU X W, WANG F, et al. Development of a monoclonal antibody-based ELISA for the detection of Alternaria mycotoxin tenuazonic acid in food samples[J]. Food Analytical Methods, 2020, 13(8):1594-1602.
[10] MAGNUS I, VIRTE M, THIENPONT H, et al. Combining optical spectroscopy and machine learning to improve food classification[J]. Food Control, 2021, 130:108342.
[11] ELLIS D I, BROADHURST D, CLARKE S J, et al. Rapid identification of closely related muscle foods by vibrational spectroscopy and machine learning[J]. The Analyst, 2005, 130(12):1648-1654.
[12] MENICHETTI G, RAVANDI B, MOZAFFARIAN D, et al. Machine learning prediction of the degree of food processing[J]. Nature Communications, 2023, 14(1):2312.
[13] CHHETRI K B. Applications of artificial intelligence and machine learning in food quality control and safety assessment[J]. Food Engineering Reviews, 2024, 16(1):1-21.
[14] RASHIDI H H, TRAN N, ALBAHRA S, et al. Machine learning in health care and laboratory medicine: General overview of supervised learning and Auto-ML[J]. International Journal of Laboratory Hematology, 2021, 43(Suppl 1):15-22.
[15] ALSUBARI S N. Data analytics for the identification of fake reviews using supervised learning[J]. Computers, Materials & Continua, 2022, 70(2):3189-3204.
[16] SEBAG M. A tour of machine learning: An AI perspective[J]. AI Communications, 2014, 27(1):11-23.
[17] INGLIS A, PARNELL A C, SUBRAMANI N, et al. Machine learning applied to the detection of mycotoxin in food: A systematic review[J]. Toxins, 2024, 16(6):268.
[18] HENDRICKX K, PERINI L, VAN DER PLAS D, et al. Machine learning with a reject option: A survey[J]. Machine Learning, 2024, 113(5):3073-3110.
[19] GOODMAN K E, LESSLER J, COSGROVE S E, et al. A clinical decision tree to predict whether a bacteremic patient is infected with an extended-spectrum β-lactamase-producing organism[J]. Clinical Infectious Diseases, 2016, 63(7):896-903.
[20] ASHINO K, SUGANO K, AMAGASA T, et al. Predicting the decision making chemicals used for bacterial growth[J]. Scientific Reports, 2019, 9(1):7251.
[21] SUN L, LIANG K B, SONG Y X, et al. An improved CNN-based apple appearance quality classification method with small samples[J]. IEEE Access, 2021, 9:68054-68065.
[22] 章海亮, 周孝文, 刘雪梅, 等. 基于卷积神经网络和高光谱成像技术的多宝鱼新鲜度鉴别[J]. 光谱学与光谱分析, 2024, 44(2):367-371.
ZHANG H L, ZHOU X W, LIU X M, et al. Freshness identification of turbot based on convolutional neural network and hyperspectral imaging technology[J]. Spectroscopy and Spectral Analysis, 2024, 44(2):367-371.
[23] 蔡健荣, 黄楚钧, 马立鑫, 等. 一维卷积神经网络的手持式可见/近红外柑橘可溶性固形物含量无损检测系统[J]. 光谱学与光谱分析, 2023, 43(9):2792-2798.
CAI J R, HUANG C J, MA L X, et al. Hand-held visible/near infrared nondestructive detection system for soluble solid content in mandarin by 1D-CNN model[J]. Spectroscopy and Spectral Analysis, 2023, 43(9):2792-2798.
[24] 刘静, 杜广全, 管骁. 基于近红外光谱的果蔬脆片品质评价方法研究[J]. 分析科学学报, 2017, 33(1):71-75.
LIU J, DU G Q, GUAN X. Study on quality evaluation of fruit and vegetable chips based on near infrared spectroscopy[J]. Journal of Analytical Science, 2017, 33(1):71-75.
[25] MANNARO K, BAIRE M, FANTI A, et al. A robust SVM color-based food segmentation algorithm for the production process of a traditional carasau bread[J]. IEEE Access, 2022, 10:15359-15377.
[26] ZOUNEMAT-KERMANI M, BATELAAN O, FADAEE M, et al. Ensemble machine learning paradigms in hydrology: A review[J]. Journal of Hydrology, 2021, 598:126266.
[27] 郭灿, 岳晓凤, 白艺珍, 等. 花生黄曲霉毒素平衡取样-随机森林风险预警模型的应用研究[J]. 中国农业科学, 2022, 55(17):3426-3449.
GUO C, YUE X F, BAI Y Z, et al. Research on the application of a balanced sampling-random forest early warning model for aflatoxin risk in peanut[J]. Scientia Agricultura Sinica, 2022, 55(17):3426-3449.
[28] WU H, PRASAD S. Semi-supervised deep learning using pseudo labels for hyperspectral image classification[J]. IEEE Transactions on Image Processing, 2018, 27(3):1259-1270.
[29] VAN ENGELEN J E, HOOS H H. A survey on semi-supervised learning[J]. Machine Learning, 2020, 109(2):373-440.
[30] MA J N, GUAN Y, XING F G, et al. Accurate and non-destructive monitoring of mold contamination in foodstuffs based on whole-cell biosensor array coupling with machine-learning prediction models[J]. Journal of Hazardous Materials, 2023, 449:131030.
[31] WANG X X, LIU C, VAN DER FELS-KLERX H J. Regional prediction of multi-mycotoxin contamination of wheat in Europe using machine learning[J]. Food Research International, 2022, 159:111588.
[32] CASTANO-DUQUE L, VAUGHAN M, LINDSAY J, et al. Gradient boosting and Bayesian network machine learning models predict aflatoxin and fumonisin contamination of maize in Illinois-First USA case study[J]. Frontiers in Microbiology, 2022, 13:1039947.
[33] WU Q S, XU L J, ZOU Z Y, et al. Rapid nondestructive detection of peanut varieties and peanut mildew based on hyperspectral imaging and stacked machine learning models[J]. Frontiers in Plant Science, 2022, 13:1047479.
[34] CHENG X Y, LI R X, XIE P D, et al. Predictive modeling of patulin accumulation in apple lesions infected by Penicillium expansum using machine learning[J]. Postharvest Biology and Technology, 2024, 217:113115.
[35] MATEO F, GADEA R, MATEO R, et al. Neural network models for prediction of trichothecene content in wheat[J]. World Mycotoxin Journal, 2008, 1(3):349-356.
[36] MATEO F, GADEA R, MATEO E M, et al. Multilayer perceptron neural networks and radial-basis function networks as tools to forecast accumulation of deoxynivalenol in barley seeds contaminated with Fusarium culmorum[J]. Food Control, 2011, 22(1):88-95.
[37] CAMARDO LEGGIERI M, MAZZONI M, FODIL S, et al. An electronic nose supported by an artificial neural network for the rapid detection of aflatoxin B1 and fumonisins in maize[J]. Food Control, 2021, 123:107722.
[38] LEGGIERI M C, MAZZONI M, BATTILANI P. Machine learning for predicting mycotoxin occurrence in maize[J]. Frontiers in Microbiology, 2021, 12:661132.
[39] HAN Z Z, GAO J Y. Pixel-level aflatoxin detecting based on deep learning and hyperspectral imaging[J]. Computers and Electronics in Agriculture, 2019, 164:104888.
[40] KIM Y, KANG S, AJANI O S, et al. Predicting early mycotoxin contamination in stored wheat using machine learning[J]. Journal of Stored Products Research, 2024, 106:102294.
[41] LIU W, DENG H Y, SHI Y L, et al. Application of multispectral imaging combined with machine learning methods for rapid and non-destructive detection of zearalenone (ZEN) in maize[J]. Measurement, 2022, 203:111944.
[42] DENG J H, NI L H, BAI X, et al. Simultaneous analysis of mildew degree and aflatoxin B1 of wheat by a multi-task deep learning strategy based on microwave detection technology[J]. LWT, 2023, 184:115047.
[43] SUN B Y, WU H Y, FANG T R, et al. Dual-mode colorimetric/SERS lateral flow immunoassay with machine learning-driven optimization for ultrasensitive mycotoxin detection[J]. Analytical Chemistry, 2025, 97(9):4824-4831.
[44] MA P H, ZHANG Z K, JIA X X, et al. Neural network in food analytics[J]. Critical Reviews in Food Science and Nutrition, 2024, 64(13):4059-4077.
[45] Rezaee Z, Mohtasebi S S, Firouz S M. Monitoring pistachio health using data fusion of machine vision and electronic nose (E-nose)[J]. Journal of Food Measurement and Characterization, 2024, 19(3): 1-8.
[46] ZHENG S Y, WEI Z S, LI S, et al. Near-infrared reflectance spectroscopy-based fast versicolorin A detection in maize for early aflatoxin warning and safety sorting[J]. Food Chemistry, 2020, 332:127419.
[47] BERTANI F R, BUSINARO L, GAMBACORTA L, et al. Optical detection of aflatoxins B in grained almonds using fluorescence spectroscopy and machine learning algorithms[J]. Food Control, 2020, 112:107073.
[48] KIM Y K, BAEK I, LEE K M, et al. Rapid detection of single- and co-contaminant aflatoxins and fumonisins in ground maize using hyperspectral imaging techniques[J]. Toxins, 2023, 15(7):472.
[49] ZHAO Y Q, ZHU C Y, JIANG H. Quantitative detection of Zearalenone in wheat using intervals selection coupled to near-infrared spectroscopy[J]. Infrared Physics & Technology, 2024, 136:105004.
[50] CEBRIÁN E, NÚÑEZ F, RODRÍGUEZ M, et al. Potential of near infrared spectroscopy as a rapid method to discriminate OTA and non-OTA-producing mould species in a dry-cured ham model system[J]. Toxins, 2021, 13(9):620.
[51] DENG J H, JIANG H, CHEN Q S. Characteristic wavelengths optimization improved the predictive performance of near-infrared spectroscopy models for determination of aflatoxin B1 in maize[J]. Journal of Cereal Science, 2022, 105:103474.
[52] 杨承霖, 刘嘉祺, 郭芸成, 等. 结合太赫兹光谱与机器学习的小麦霉变程度判别[J]. 食品科学, 2023, 44(12):343-350.
YANG C L, LIU J Q, GUO Y C, et al. Detection of mildew degree of wheat using terahertz spectroscopy and machine learning[J]. Food Science, 2023, 44(12):343-350.
[53] DIB A A, ASSAF J C, DEBS E, et al. A comparative review on methods of detection and quantification of mycotoxins in solid food and feed: a focus on cereals and nuts[J]. Mycotoxin Research, 39: 319-345.
[54] KIM D Y, GETACHEW F, TILLMAN B L, et al. Developing statistical models of aflatoxin risk in peanuts using historical weather data[J]. Agronomy Journal, 2024, 116(5):2346-2361.
[55] KIM Y K, QIN J W, BAEK I, et al. Detection of aflatoxins in ground maize using a compact and automated Raman spectroscopy system with machine learning[J]. Current Research in Food Science, 2023, 7:100647.
[56] ZHANG S, LI Z X, AN J, et al. Identification of aflatoxin B1 in peanut using near-infrared spectroscopy combined with naive Bayes classifier[J]. Spectroscopy Letters, 2021, 54(5):340-351.
[57] 赵雪, 靳欣迪, 刘斌, 等. 辣椒粉中黄曲霉菌生长及其产毒规律的预测模型构建[J]. 食品科学, 2021, 42(14):62-69.
ZHAO X, JIN X D, LIU B, et al. Prediction model construction for Aspergillus flavus growth and toxin accumulation in chili powder[J]. Food Science, 2021, 42(14):62-69.
[58] RANBIR, SINGH G, KAUR N, et al. Machine learning driven metal oxide-based portable sensor array for on-site detection and discrimination of mycotoxins in corn sample[J]. Food Chemistry, 2025, 464(Pt 3):141869.
[59] WANG Q A, CHEN J, NI Y Q, et al. Application of Bayesian networks in reliability assessment: A systematic literature review[J]. Structures, 2025, 71:108098.
[60] RAHMAT F, ZULKAFLI Z, ISHAK A J, et al. Supervised feature selection using principal component analysis[J]. Knowledge and Information Systems, 2024, 66(3):1955-1995.
[61] ATAŞ M, YARDIMCI Y, TEMIZEL A. A new approach to aflatoxin detection in chili pepper by machine vision[J]. Computers and Electronics in Agriculture, 2012, 87:129-141.
[62] LI S L, SHAO X J, GUO Z, et al. Novel detection method for Aspergillus flavus contamination in maize kernels based on spatial-spectral features using short-wave infrared hyperspectral imaging[J]. Journal of Food Composition and Analysis, 2025, 140:107219.
[63] 王蓓, 沈飞, 何学明, 等. 电子鼻同步检测花生霉菌及霉菌毒素[J]. 食品科学, 2022, 43(12): 310-316.
WANG B, SHEN F, HE X M, et al.Simultaneous Detection of Harmful Fungi and Mycotoxin Contamination in Peanuts by Electronic Nose[J]. Food Science, 2022, 43(12): 310-316.
[64] CHEN M, HE X M, PANG Y Y, et al. Laser induced fluorescence spectroscopy for detection of Aflatoxin B1 contamination in peanut oil[J]. Journal of Food Measurement and Characterization, 2021, 15(3):2231-2239.
[65] WANG B, SHEN F, HE X M, et al. Simultaneous detection of Aspergillus moulds and aflatoxin B1 contamination in rice by laser induced fluorescence spectroscopy[J]. Food Control, 2023, 145:109485.
[66] SALEHI A, KHEDMATI M. Hybrid clustering strategies for effective oversampling and undersampling in multiclass classification[J]. Scientific Reports, 2025, 15(1):3460.
[67] RABBANI Y, BEHJATI S, LAMBERT B, et al. Prediction of mycotoxin response of DNA-wrapped nanotube sensor with machine learning[J]. ECS Meeting Abstracts, 2023, MA2023-01(10):1223.
[68] PURCHASE J, DONATO R, SACCO C, et al. The association of food ingredients in breakfast cereal products and fumonisins production: Risks identification and predictions[J]. Mycotoxin Research, 2023, 39(3):165-175.
[69] ROCCHETTI G, GHILARDELLI F, MASOERO F, et al. Screening of regulated and emerging mycotoxins in bulk milk samples by high-resolution mass spectrometry[J]. Foods, 2021, 10(9):2025.
[70] 陈靓, 阳佳红, 田星. 机器学习在食品风味领域的研究进展与未来趋势[J]. 食品科学, 2024, 45(10): 28-37.
CHEN J, YANG J H, TIAN X. Research Progress and Future Trends of Machine Learning in the Field of Food Flavor[J]. Food Science, 2024, 45(10): 28-37.
[71] 郭香兰, 王立, 金学波, 等. 机器学习-基于GAN和DF结合的粮食加工过程污染物小样本数据扩充及预测[J]. 食品科学, 2024, 45(12): 22-30.
GUO X L, YU L, JIN X B, et al. Machine Learning-Small Sample Data Expansion and Prediction of Pollutants in the Grain Processing Process Based on the Combination of GAN and DF[J]. Food Science, 2024, 45(12): 22-30.
[72] KOYAMA H. Machine learning application in otology[J]. Auris, Nasus, Larynx, 2024, 51(4):666-673.
[73] BANG J, YANG B. Application of machine learning to predict the engineering characteristics of construction material[J]. Multiscale Science and Engineering, 2023, 5(1):1-9.
[74] LOU R R, LV Z H, DANG S P, et al. Application of machine learning in ocean data[J]. Multimedia Systems, 2023, 29(3):1815-1824.
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