This study used Cordyceps militaris and corn peptides as major materials to develop a functional drink that is antioxidative, antihypertensive, immunoregulatory and able to reduce thrombosis. The optimal formula of the drink was determined by orthogonal experiments. The results showed that when the ratio of Cordyceps militaris extract to rose water was 2∶1, with 10 g/L corn peptides, 1 g/L ethyl maltol, 80 g/L honey, and 0.15 g/L citric acid, the color, taste, and smell of the drink were the best. Under this condition, the activity of fibrinolytic enzyme in the drink was 2.78 U/mL, and the contents of cordycepin and polysaccharide were 12.43 μg/mL and 199 mg/mL, respectively. Moreover, the scavenging effects of each milliliter of the drink on DPPH·,·OH, as well as its reducing power were equivalent to 20 μg, 40 μg, and 20 μg Vc, respectively. In conclusion, this study provides some ideas for developing functional foods based on Cordyceps militaris, which has great significance for its utilization.
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