[1] LI S,TAN H Y,WANG N, et al. The role of oxidative stress and antioxidants in liver diseases[J]. International Journal of Molecular Sciences, 2015, 16(11): 26 087-26 124.
[2] GILGUN-SHERKI Y,MELAMED E,OFFEN D. Oxidative stress induced-neurodegenerative diseases: the Need for Antioxidants That Penetrate the Blood Brain Barrier[J]. Neuropharmacology, 2001, 40(8): 959-975.
[3] KLEIN J A,ACKERMAN S L. Oxidative stress, cell cycle, and neurodegeneration[J]. Journal of Clinical Investigation, 2003, 111(6): 785-793.
[4] WARIS G,AHSAN H. Reactive Oxygen Species: Role in the Development of Cancer and Various Chronic Conditions[J]. Journal of Carcinogenesis, 2006, 5(1): 14.
[5] LEE J,KOO N,MIN D B. Reactive Oxygen Species, Aging, and antioxidative nutraceuticals[J]. Comprehensive Reviews in Food Science and Food Safety, 2004, 3(1): 21-33.
[6] LOENN M E,DENNIS J M,STOCKER R. Actions of "antioxidants" in the protection against atherosclerosis[J]. Free Radical Biology and Medicine, 2012, 53(4): 863-884.
[7] SUGAMURA K,KEANEY J F. Reactive oxygen species in cardiovascular disease[J]. Free Radical Biology and Medicine, 2011, 51(5): 978-992.
[8] ZHOU D,WANG W,CHENG X, et al. Antioxidant therapy for patients with chronic pancreatitis: A systematic review and meta-analysis[J]. Clinical Nutrition, 2015, 34(4): 627-634.
[9] VALKO M,LEIBFRITZ D,MONCOL J, et al. Free radicals and antioxidants in normal physiological functions and human disease[J]. The International Journal of Biochemistry & Cell Biology, 2007, 39(1): 44-84.
[10] NIKI E. Assessment of antioxidant capacity in vitro and in vivo[J]. Free Radical Biology and Medicine, 2010, 49(4): 503-515.
[11] GAD A S,KHADRAWY Y A,EI-NEKEETY A A, et al. Antioxidant activity and hepatoprotective effects of whey protein and spirulina in rats[J]. Nutrition, 2011, 27(5): 582-589.
[12] LE-MAUX S,NONGONIERMA A B,BARRE C, et al. Enzymatic generation of whey protein hydrolysates under pH-controlled and non pH-controlled Conditions: Impact on physicochemical and bioactive properties[J]. Food Chemistry, 2016, 199: 246-251.
[13] DRYÁKOVÁ A,PIHLANTO A,MARNILA P, et al. Antioxidant properties of whey protein hydrolysates as measured by three methods[J]. European Food Research and Technology, 2010, 230(6): 865-874.
[14] O′KEEFFE M B,FITZGERALD R J. Antioxidant effects of enzymatic hydrolysates of whey protein concentrate on cultured human endothelial cells[J]. International Dairy Journal, 2014, 36(2): 128-135.
[15] ZHANG Q X,WU H,LING Y F, et al. Isolation and Identification of antioxidant peptides derived from whey protein enzymatic hydrolysate by consecutive chromatography and Q-TOFf MS[J]. Journal of Dairy Research, 2013, 80(3): 367-373.
[16] LIN S,TIAN W,LI H, et al. Improving antioxidant activities of whey protein hydrolysates obtained by thermal preheat treatment of pepsin, trypsin, alcalase and flavourzyme: Improve antioxidant activities of whey protein[J]. International Journal of Food Science and Technology, 2012, 47(10): 2 045-2 051.
[17] ADJONU R,DORAN G,TORLEY P, et al. Screening of whey protein isolate hydrolysates for their dual functionality: Influence of heat pre-treatment and enzyme specificity[J]. Food Chemistry, 2013, 136(3-4): 1 435-1 443.
[18] PENG X,KONG B,XIA X, et al. Reducing and radical-scavenging activities of whey protein hydrolysates prepared with alcalase[J]. International Dairy Journal, 2010, 20(5): 360-365.
[19] ÕNAY-UCAR E,ARDA N,PEKMEZ M, et al. Comparison of antioxidant capacity, protein profile and carbohydrate content of whey protein fractions[J]. Food Chemistry, 2014, 150: 34-40.
[20] MANN B,KUMARI A,KUMAR R, et al. Antioxidant activity of whey protein hydrolysates in milk beverage system[J]. Journal of Food Science & Technology, 2015, 52(6): 3 235-3 241.
[21] BERTUCCI J I,LIGGIERI C S,COLOMBO M L, et al. Application of peptidases from maclura pomifera fruit for the production of active biopeptides from whey protein[J]. Lwt - Food Science and Technology, 2015, 64(1): 157-163.
[22] HERNÕNDEZ-LEDESMA B,DÕVALOS A,BARTOLOMÉ B, et al. Preparation of antioxidant enzymatic hydrolysates from α-lactalbumin and β-lactoglobulin. Identification of active peptides by HPLC-MS/MS[J]. Journal of Agricultural and Food Chemistry, 2005, 53(3): 588-593.
[23] NONGONIERMA A B,FITZGERALD R J. Inhibition of dipeptidyl peptidase Iv (dpp-iv) by tryptophan containing dipeptides[J]. Food & Function, 2013, 4(12): 1 843-1 849.
[24] SADAT L,CAKIR-KIEFER C,N’NEGUE M A, et al. Isolation and identification of antioxidative peptides from bovine α-lactalbumin[J]. International Dairy Journal, 2011, 21(4): 214-221.
[25] CHEN H,MURAMOTO K,YAMAUCHI F, et al. Antioxidative properties of histidine-containing peptides designed from peptide fragments found in the digests of a soybean protein[J]. Journal of Agricultural and Food Chemistry, 1998, 46(1): 49-53.
[26] POWER O,JAKEMAN P,FITZGERALD R J. Antioxidative peptides: Enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides[J]. Amino Acids, 2013, 44(3): 797-820.
[27] CHAN K M,DECKER E A, FEVSTMAN C. Endogenous skeletal muscle antioxidants[J]. Critical Reviews in Food Science & Nutrition, 1994, 34(4): 403-426.
[28] YAO-WANG L,BO L,JIGUO H, et al. Structure-activity relationship study of antioxidative peptides by qsar modeling: the amino acid next to C-terminus affects the activity[J]. Journal of Peptide Science, 2011, 17(6): 454-462.
[29] LIANG N,KITTS D D. Antioxidant property of coffee components: Assessment of methods that define mechanisms of action[J]. Molecules, 2014, 19(11): 19 180-19 208.
[30] CORREA APF,DAROIT D J,COELHO J G, et al. Antioxidant, antihypertensive and antimicrobial properties of ovine milk caseinate hydrolyzed with a microbial protease[J]. Journal of the Science of Food and Agriculture, 2011, 91(12): 2 247-2 254.
[31] BENZIE I F F,STRAIN J J. The ferric reducing ability of plasma (frap) as a measure of "antioxidant power": The FRAP assay[J]. Analytical Biochemistry, 1996, 239(1): 70-76.
[32] OU B,HAMPSCH-WOODILL M,PRIOR R L. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe[J]. Journal of Agricultural and Food Chemistry, 2001, 49(10): 4 619-4 626.
[33] TSENG Y M, LIN S K,HSIAO J K, et al. Whey protein concentrate promotes the production of glutathione (gsh) by gsh reductase in the Pc12 cell line after acute ethanol exposure[J]. Food & Chemical Toxicology, 2006, 44(4): 574-578.
[34] PYO M C,YANG S Y,CHUN S H, et al. Protective effects of maillard reaction products of whey protein concentrate against oxidative stress through an Nrf2-dependent pathway in Hepg2 cells[J]. Biological & Pharmaceutical Bulletin, 2016, 39(9): 1 437.
[35] XU R,LIU N,XU X, et al. Antioxidative effects of whey protein on peroxide-induced cytotoxicity[J]. Journal of Dairy Science, 2011, 94(8): 3 739-3 746.
[36] KONG B,PENG X,XIONG Y L, et al. Protection of lung fibroblast mrc-5 cells against hydrogen peroxide-induced oxidative damage by 0.1-2.8 KDA antioxidative peptides isolated from whey protein hydrolysate[J]. Food Chemistry, 2012, 135(2): 540-547.
[37] PURPURA M,LOWERY R P,JOY J M, et al. A comparison of blood amino acid concentrations following ingestion of rice and whey protein isolate: A double-blind, crossover study[J]. J Nutr Health Sci, 2014, 1(3): 306.
[38] POWER-GRANT O,BRUEN C,BRENNAN L, et al. In vitro bioactive properties of intact and enzymatically hydrolysed whey protein: Targeting the enteroinsular axis[J]. Food & Function, 2015, 6(3): 972-980.
[39] PICCOLOMINI A F,ISKANDAR M M,LANDS L C, et al. High hydrostatic pressure pre-treatment of whey proteins enhances whey protein hydrolysate inhibition of oxidative stress and Il-8 secretion in intestinal epithelial cells[J]. Food & Nutrition Research, 2012, 56(1): 17 549.
[40] CORROCHANO A R,FERRARETTO A,ARRANZ E, et al. Bovine whey peptides transit the intestinal barrier to reduce oxidative stress in muscle cells[J]. Food Chemistry, 2019, 288: 306-314.
[41] JOUBRAN Y,MOSCOVICI A,LESMES U. Antioxidant activity of bovine alpha lactalbumin maillard products and evaluation of their in vitro gastro-duodenal digestive proteolysis[J]. Food & Function, 2015, 6(4): 1 229-1 240.
[42] GOLD P. The influence of dietary whey protein on tissue glutathione and the diseases of aging[J]. Clin Invest Med, 1989, 12(6): 343-349.
[43] ASHOUSH I S,EL-BATAWY O I,EL-SHOURBAGY G A. Antioxidant activity and hepatoprotective effect of pomegranate peel and whey powders in rats[J]. Annals of Agricultural Sciences, 2013, 58(1): 27-32.
[44] KIM J,PAIK H D,YOON Y C, et al. Whey protein inhibits iron overload-induced oxidative stress in rats[J]. Journal of Nutritional Science and Vitaminology, 2013, 59(3): 198-205.
[45] ATHIRA S,MANN B,SHARMA R, et al. Ameliorative potential of whey protein hydrolysate against paracetamol-induced oxidative stress[J]. Journal of Dairy Science, 2013, 96(3): 1 431-1 437.
[46] HARAGUCHI F K,SILVA M E,NEVES L X, et al. Whey protein precludes lipid and protein oxidation and improves body weight gain in resistance-exercised rats[J]. European Journal of Nutrition, 2011, 50(5): 331-339.
[47] MIDDLETON N,JELEN P,BELL G. Whole blood and mononuclear cell glutathione response to dietary whey protein supplementation in sedentary and trained male human subjects[J]. International Journal of Food Sciences and Nutrition, 2004, 55(2): 131-141.
[48] SHEIKHOLESLAMI D V,AHMADI F K G. Changes in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance training[J]. Appetite, 2012, 59(3): 673-678.
[49] CHITAPANARUX T,TIENBOON P,POJCHAMARNWIPUTH S, et al. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients[J]. Journal of Gastroenterology and Hepatology, 2009, 24(6): 1 045-1 050.
[50] ZAVORSKY G S,KUBOW S,GREY V, et al. An Open-label dose-response study of lymphocyte glutathione levels in healthy men and women receiving pressurized whey protein isolate supplements[J]. International Journal of Food Sciences and Nutrition, 2007, 58(6): 429-436.
[51] SHIMIZU H,KIYOHARA Y,KATO I, et al. Relationship between plasma glutathione levels and cardiovascular disease in a defined population: The hisayama study[J]. Stroke, 2004, 35(9): 2 072-2 077.