食品与发酵工业 >

2024 , Vol. 50 >Issue 11: 360 - 366

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.038843

综述与专题评论

刺激响应型DNA水凝胶的设计合成及其在食品安全领域的研究进展

  • 张鸿鹏 ,
  • 谢刚 ,
  • 李可敬 ,
  • 罗菲 ,
  • 窦金鑫 ,
  • 朱道兴 ,
  • 郭玉垚 ,
  • 韩逸陶
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  • 1(上海理工大学 健康科学与工程学院,上海,200082)
    2(国家粮食和物资储备局科学研究院,北京,100037)
    3(武汉轻工大学 食品科学与工程学院,湖北 武汉,430043)
第一作者:硕士研究生(谢刚研究员和韩逸陶副研究员为共同通信作者,E-mail:xg@ags.ac.cn;hyt@ags.ac.cn)

收稿日期: 2024-02-06

  修回日期: 2024-02-26

  网络出版日期: 2024-07-12

基金资助

国家自然科学基金青年项目(32102066);“十四五”国家重点研发计划项目(2023YFF1104603)

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Design and synthesis of stimulus responsive DNA hydrogel and its research progress in the field of food safety

  • ZHANG Hongpeng ,
  • XIE Gang ,
  • LI Kejing ,
  • LUO Fei ,
  • DOU Jinxin ,
  • ZHU Daoxing ,
  • GUO Yuyao ,
  • HAN Yitao
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  • 1(School of Healthy Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200082, China)
    2(Academy of National Food and Strategic Reserves Administration, Beijing 100037, China)
    3(School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430043, China)

Received date: 2024-02-06

  Revised date: 2024-02-26

  Online published: 2024-07-12

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摘要

具有三维网络结构的DNA水凝胶,因其既具备DNA的生物学特性又兼具水凝胶的骨架功能而备受关注,又由于其具有良好的稳定性和特异性识别能力,可以对多种信号响应,并在凝胶和溶胶之间转换,在生物传感方面得到了广泛的应用。该文围绕DNA水凝胶的合成、刺激信号类型以及在食品安全领域的应用进行综述。根据合成方法的不同分为物理和化学合成方法,按照刺激信号的类型又可以分为温度响应型、pH响应型、光子响应型、生物分子响应型和多重响应型刺激信号的DNA水凝胶,总结了DNA水凝胶在食品安全领域应用于真菌毒素、重金属离子、食源性致病菌、抗生素残留、非法添加剂检测的研究进展,并对其发展前景进行了阐述。

关键词： DNA水凝胶; 刺激响应; 生物传感; 特异性识别; 食品安全

本文引用格式

张鸿鹏 , 谢刚 , 李可敬 , 罗菲 , 窦金鑫 , 朱道兴 , 郭玉垚 , 韩逸陶 . 刺激响应型DNA水凝胶的设计合成及其在食品安全领域的研究进展[J]. 食品与发酵工业, 2024 , 50(11) : 360 -366 . DOI: 10.13995/j.cnki.11-1802/ts.038843

Abstract

DNA hydrogel with three-dimensional network structure has been attracted much attention due to its biological characteristics of DNA and the skeleton function of hydrogel.According to its good stability and specific recognition ability, it can respond to a variety of signals and convert between gel and sol.It has been widely used in biosensing. This study focuses on the synthesis of DNA hydrogels, the types of stimulation signals, and their applications in the field of food safety.According to the different synthesis methods, it can be divided into physical and chemical synthesis methods, and according to the type of stimulus signal, it can be divided into temperature-responsive, pH-responsive, photon-responsive, biomolecular responsive and multi-responsive stimulus signal DNA hydrogels.The research progress of DNA hydrogel in the field of food safety for the detection of mycotoxins, heavy metal ions, foodborne pathogenic bacteria, antibiotic residues and illegal additives is summarized, and its development prospects are expounded.

Key words： DNA hydrogel; stimulus-responsive; biosensing; specific recognition; food safety

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